Miltefosine: a review of its pharmacology and therapeutic efficacy in the treatment of leishmaniasis.
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Summary
The pharmacokinetics of miltefosine are mainly characterized by its long residence time in the body, resulting in extensive drug accumulation during treatment and long elimination half-lives, which severely hampers its general use in the clinic and roll-out in national elimination programmes.
- Type
- article
- Published
- 2012-11-01
- Cited by
- 705
- References
- 185
- Access
- Open access
- OpenAlex
- https://openalex.org/W22833634
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:34096652
Keywords
Aerodynamics, Aerodynamic force, Force transducer, Displacement (psychology), Wind tunnel
References
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- Miltefosine Promotes IFN-γ-Dominated Anti-Leishmanial Immune Response1
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- Effects of hexadecylphosphocholine on phosphatidylcholine and phosphatidylserine metabolism in human lymphoma cells.
Cited by
- Drug Discovery for Neglected Diseases: Molecular Target-Based and Phenotypic Approaches
- Failure of miltefosine in visceral leishmaniasis is associated with low drug exposure.
- How pH Modulates the Dimer-Decamer Interconversion of 2-Cys Peroxiredoxins from the Prx1 Subfamily*
- Further characterization of a secreted lipase from the human pathogen Leishmania donovani by determining the effect of various metal ions on its enzymatic activity.
- Phenotypic and Genotypic Analysis of in vitro Selected Miltefosine Resistant Leishmania donovani
- Molecular descriptors calculation as a tool in the analysis of the antileishmanial activity achieved by two series of diselenide derivatives. An insight into its potential action mechanism.
- (-)-α-Bisabolol, a Promising Oral Compound for the Treatment of Visceral Leishmaniasis.
- Role of phosophoinositide-based signaling in virulence in Entamoeba histolytica
- Arsenic, antimony and visceral leishmaniasis
- Inhibition of Granulomatous Inflammation and Prophylactic Treatment of Schistosomiasis with a Combination of Edelfosine and Praziquantel
- Fitness and Phenotypic Characterization of Miltefosine-Resistant Leishmania major
- Use of polyomics approaches to understanding drug resistance in kinetoplatid protozoa
- Antileishmanial activity and evaluation of the mechanism of action of strychnobiflavone flavonoid isolated from Strychnos pseudoquina against Leishmania infantum
- Long-term follow-up of dogs with leishmaniosis treated with meglumine antimoniate plus allopurinol versus miltefosine plus allopurinol
- Evaluation of the efficacy of systemic miltefosine associated with photodynamic therapy with liposomal chloroaluminium phthalocyanine in the treatment of cutaneous leishmaniasis caused by Leishmania (L.) amazonensis in C57BL/6 mice.
- Lack of correlation between the promastigote back-transformation assay and miltefosine treatment outcome.
- Leishmania cell wall as a potent target for antiparasitic drugs. A focus on the glycoconjugates.
- The effect of the phytol-rich fraction from Lacistema pubescens against Leishmania amazonensis is mediated by mitochondrial dysfunction.
- Medicinal organometallic chemistry – an emerging strategy for the treatment of neglected tropical diseases
- Pharmacotherapy for Leishmaniasis in the United States: Focus on Miltefosine
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