Molecular basis for the differential sensitivity of rat and human α9α10 nAChRs to α-conotoxin RgIA
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- Type
- article
- Published
- 2012-08-03
- Cited by
- 89
- References
- 79
- Access
- Open access
- OpenAlex
- https://openalex.org/W22774872
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:19258150
Keywords
Cross disciplinary, Computer science, Data science
References
- Phenotypical and molecular profiling of the extraneuronal cholinergic system of the skin.
- Discovery of non-peptide, small molecule antagonists of α9α10 nicotinic acetylcholine receptors as novel analgesics for the treatment of neuropathic and tonic inflammatory pain
- Determinants of specificity for alpha-conotoxin MII on alpha3beta2 neuronal nicotinic receptors.
- A new alpha-conotoxin which targets alpha3beta2 nicotinic acetylcholine receptors.
- Analgesic conotoxins: block and G protein‐coupled receptor modulation of N‐type (CaV2.2) calcium channels
- Biophysical and pharmacological characterization of nicotinic cholinergic receptors in rat cochlear inner hair cells
- Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors
- Alpha-conotoxin PIA is selective for alpha6 subunit-containing nicotinic acetylcholine receptors.
- Synthetic α-Conotoxin Mutants as Probes for Studying Nicotinic Acetylcholine Receptors and in the Development of Novel Drug Leads
- Abstract 1084: Naturally occurring variants of human α9 nicotinic receptor differentially affect bronchial cell proliferation and transformation
- Characterization of Nicotinic Acetylcholine Receptors That Modulate Nicotine-Evoked [3H]Norepinephrine Release from Mouse Hippocampal Synaptosomes
- Coexpression of alpha 9 and alpha 10 nicotinic acetylcholine receptors in rat dorsal root ganglion neurons.
- Identification of Residues in the Neuronal α7Acetylcholine Receptor That Confer Selectivity for Conotoxin ImI*
- Nicotinic acetylcholine receptor subtypes in nociceptive dorsal root ganglion neurons of the adult rat.
- Alpha-RgIA, a novel conotoxin that blocks the alpha9alpha10 nAChR: structure and identification of key receptor-binding residues.
- Synergistic control of keratinocyte adhesion through muscarinic and nicotinic acetylcholine receptor subtypes.
- Structural determinants of selective alpha-conotoxin binding to a nicotinic acetylcholine receptor homolog AChBP.
- A novel mechanism of inhibition of high‐voltage activated calcium channels by α‐conotoxins contributes to relief of nerve injury‐induced neuropathic pain
- Targeting the alpha9alpha10 nicotinic acetylcholine receptor to treat severe pain.
- The three‐dimensional structure of the analgesic α‐conotoxin, RgIA
Cited by
- αS-Conotoxin GVIIIB Potently and Selectively Blocks α9α10 Nicotinic Acetylcholine Receptors
- Investigating epileptiform activity associated with slow wave sleep
- Less is More: Design of a Highly Stable Disulfide-Deleted Mutant of Analgesic Cyclic α-Conotoxin Vc1.1
- Cloning, synthesis, and characterization of αO-conotoxin GeXIVA, a potent α9α10 nicotinic acetylcholine receptor antagonist
- 6-Bromohypaphorine from Marine Nudibranch Mollusk Hermissenda crassicornis is an Agonist of Human α7 Nicotinic Acetylcholine Receptor
- Determination of the α-conotoxin Vc1.1 binding site on the α9α10 nicotinic acetylcholine receptor.
- Neuronal nicotinic receptors as analgesic targets: It’s a winding road
- Alanine Scan of α-Conotoxin RegIIA Reveals a Selective α3β4 Nicotinic Acetylcholine Receptor Antagonist*
- Presence of multiple binding sites on α9α10 nAChR receptors alludes to stoichiometric dependent action of the α-conotoxin, Vc1.1
- Pharmacologically Distinct Nicotinic Acetylcholine Receptors Drive Efferent-Mediated Excitation in Calyx-Bearing Vestibular Afferents
- Conotoxins Targeting Nicotinic Acetylcholine Receptors: An Overview
- Discovery, synthesis and development of structure-activity relationships of Conotoxins
- Molecular Interaction of α-Conotoxin RgIA with the Rat α9α10 Nicotinic Acetylcholine Receptor
- Nicotinic receptors in non-human primates: analysis of genetic and functional conservation with humans
- Crystal structures of free and antagonist-bound states of human α9 nicotinic receptor extracellular domain
- Conotoxin Interactions with α9α10-nAChRs: Is the α9α10-Nicotinic Acetylcholine Receptor an Important Therapeutic Target for Pain Management?
- Molecular Basis for Differential Sensitivity of α-Conotoxin RegIIA at Rat and Human Neuronal Nicotinic Acetylcholine Receptors
- New quinoline derivatives as nicotinic receptor modulators.
- Dicarba analogues of α-conotoxin RgIA. Structure, stability, and activity at potential pain targets.
- Conotoxin αD-GeXXA utilizes a novel strategy to antagonize nicotinic acetylcholine receptors
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