Tumor-Associated Macrophages in Pediatric Classical Hodgkin Lymphoma: Association with Epstein-Barr Virus, Lymphocyte Subsets, and Prognostic Impact
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Summary
The results suggest that macrophage composition in pediatric cHL is distinct from adults, and functional status of macrophages and their value as prognostic indicators in children's cHL may depend on EBV status.
- Type
- article
- Published
- 2012-05-29
- Cited by
- 86
- References
- 48
- Access
- Open access
- OpenAlex
- https://openalex.org/W2100745352
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:22245198
Keywords
Lymphoma, Virus, Medicine, Immunology, Lymphocyte
References
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- The classical Hodgkin's lymphoma microenvironment and its role in promoting tumour growth and immune escape
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- Blood T and B lymphocyte subpopulations in healthy infants and children
- Molecular profiling of classical Hodgkin lymphoma tissues uncovers variations in the tumor microenvironment and correlations with EBV infection and outcome.
- Tumor microenvironment composition in pediatric classical Hodgkin lymphoma is modulated by age and Epstein‐Barr virus infection
- Expression of CD68 in Non‐Myeloid Cell Types
- Human plasmacytoid-derived dendritic cells and the induction of T-regulatory cells.
- Refined Prognostic Role of CD68-Positive Tumor Macrophages in the Context of the Cellular Micromilieu of Classical Hodgkin Lymphoma
- Age-related changes in human blood lymphocyte subpopulations.
- Prognostic implication of types of tumor-associated macrophages in Hodgkin lymphoma
- Specific infiltration of langerin‐positive dendritic cells in EBV‐infected tonsil, Hodgkin lymphoma and nasopharyngeal carcinoma
- Dendritic cell subsets in childhood and in children with cancer: relation to age and disease prognosis
Cited by
- CD163+CD14+ macrophages, a potential immune biomarker for malignant pleural effusion
- Macrophage Polarization Reflects T Cell Composition of Tumor Microenvironment in Pediatric Classical Hodgkin Lymphoma and Has Impact on Survival
- Toll-like receptor 4-induced inflammatory responses contribute to the tumor-associated macrophages formation and infiltration in patients with diffuse large B-cell lymphoma.
- Role of tumor‐associated macrophages in hematological malignancies
- The absolute lymphocyte to monocyte ratio is associated with poor prognosis in classical Hodgkin lymphoma patients younger than 60 years of age
- Clinical Significance of sIL-2R Levels in B-Cell Lymphomas
- How do viruses trick B-cells into becoming lymphomas?
- Macrophages and Dendritic Cells as Actors in the Immune Reaction of Classical Hodgkin Lymphoma
- Plasma Epstein-Barr virus DNA predicts outcome in advanced Hodgkin lymphoma: correlative analysis from a large North American cooperative group trial.
- Macrophage Polarisation: an Immunohistochemical Approach for Identifying M1 and M2 Macrophages
- The classical Hodgkin lymphoma tumor microenvironment: macrophages and gene expression-based modeling.
- The prognostic impact of tumour-associated macrophages and Reed-Sternberg cells in paediatric Hodgkin lymphoma.
- Immunotherapy in pediatric malignancies: current status and future perspectives
- CD163 immunohistochemistry is superior to CD68 in predicting outcome in classical Hodgkin lymphoma.
- Pediatric Hodgkin Lymphoma in a South Indian Regional Cancer Center: Its Immunomorphology, Tumor-Associated Macrophages, and Association with Epstein–Barr Virus
- New targets for antibody therapy of pediatric B cell lymphomas
- Serum CD163 and TARC as Disease Response Biomarkers in Classical Hodgkin Lymphoma
- High tumour-associated macrophages infiltration is correlated with poor survival outcome in classical Hodgkin’s lymphoma
- Epidemiology of Epstein-Barr virus-associated pediatric lymphomas from Argentina.
- The role of tumour‐infiltrating eosinophils, mast cells and macrophages in Classical and Nodular Lymphocyte Predominant Hodgkin Lymphoma in children
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