End-to-end self-assembly of RADA 16-I nanofibrils in aqueous solutions.
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Summary
RADA 16-I is a synthetic amphiphilic peptide designed to self-assemble in a controlled way into fibrils and higher ordered structures depending on pH, and it is found that the aggregation process is not limited by diffusion but rather is an activated process with energy barrier in the order of 20 kcal/mol.
- Type
- article
- Published
- 2012-04-04
- Cited by
- 58
- References
- 47
- Access
- Open access
- OpenAlex
- https://openalex.org/W22500762
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:45354213
Keywords
Radiochemistry, Medical physics, Chemistry, Materials science, Physics
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- The effects of motif net charge and amphiphilicity on the self-assembly of functionally designer RADA16-I peptides
- A Colloidal Description of Intermolecular Interactions Driving Fibril-Fibril Aggregation of a Model Amphiphilic Peptide.
- Role of filament annealing in the kinetics and thermodynamics of nucleated polymerization.
- Sol-gel transition of charged fibrils composed of a model amphiphilic peptide.
- Sustained and controlled release of lipophilic drugs from a self-assembling amphiphilic peptide hydrogel.
- Kinetic theory of protein filament growth: Self-consistent methods and perturbative techniques
- All-Atom Molecular Dynamics Study of Four RADA 16-I Peptides: The Effects of Salts on Cluster Formation
- Spacer driven morphological twist in Phe-Phe dipeptide conjugates
- On the lag phase in amyloid fibril formation
- Molecular Structure of RADA16-I Designer Self-Assembling Peptide Nanofibers
- Evaluation of the hemocompatibility and rapid hemostasis of (RADA)4 peptide-based hydrogels.
- Morphology and aggregation of RADA‐16‐I peptide Studied by AFM, NMR and molecular dynamics simulations
- Self-Assembly of Peptide Amphiphiles: Molecularly Engineered Bionanomaterials
- Contribution of Electrostatics in the Fibril Stability of a Model Ionic-Complementary Peptide.
- Bioprinting synthetic self-assembling peptide hydrogels for biomedical applications
- Clotting Mimicry from Robust Hemostatic Bandages Based on Self-Assembling Peptides
- Stability and aggregation kinetics of colloidal systems: application to polymer colloids, proteins and peptides
- Functional Self-Assembling Peptide Nanofiber Hydrogels Designed for Nerve Degeneration.