Synthesis, antimicrobial evaluation and QSAR analysis of novel nalidixic acid based 1,2,4-triazole derivatives.
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Summary
Based on the QSAR analysis, it is indicative that lipophilic and steric parameters are the pre-requisites for these molecules to act as potent antimicrobial agents.
- Type
- article
- Published
- 2011-09-01
- Cited by
- 79
- References
- 43
- OpenAlex
- https://openalex.org/W21752498
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:23184190
Keywords
Computer science
References
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- Design, synthesis and QSAR study of arylidene indoles as anti-platelet aggregation inhibitors
- Chemical analysis of essential oils of Eupatorium adenophorum and their antimicrobial, antioxidant and phytotoxic properties
- Synthesis, molecular docking of novel 1,8-naphthyridine derivatives and their cytotoxic activity against HepG2 cell lines
- Triazolothiadiazoles and triazolothiadiazines--biologically attractive scaffolds.
- One-pot synthesis of novel isoindoline-1,3-dione derivatives bearing 1,2,4-triazole moiety and their preliminary biological evaluation.
- A copper-mediated cross-coupling approach for the synthesis of 3-heteroaryl quinolone and related analogues.
- Synthesis and biological activity of tri-substituted 1,2,4-triazoles bearing benzimidazole moiety
- Complexation of manganese(II), cobalt(II), nickel(II) and copper(II) by a ligand derived from 1,2,4-triazole: Potentiometric studies and Density Functional Theory calculations
- Synthesis and anticancer activity of long chain substituted 1,3,4-oxadiazol-2-thione, 1,2,4-triazol-3-thione and 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazine derivatives
- Synthesis, characterization, and antimicrobial evaluation of some new hydrazinecarbothioamide, 1,2,4-triazole and 1,3,4-thiadiazole derivatives
- Effect of nalidixic acid on the morphology and protein expression of Pseudomonas aeruginosa.
- Synthesis, characterization, DNA interactions, DNA cleavage, radical scavenging activity, antibacterial, anti-proliferative and docking studies of new transition metal complexes
- Microwave synthesis, characterization and bio-efficacy evaluation of novel chalcone based 6-carbethoxy-2-cyclohexen-1-one and 2H-indazol-3-ol derivatives.
- An approach to design antimicrobial agents by 2D QSAR studies on series of 5, 5-diphenylimidazolidine-2, 4-dione derivatives
- Advances in 1,8-Naphthyridines Chemistry
- Turning renewable resources into value-added products: Development of rosin-based insecticide candidates
- Immobilization of hydrophilic low molecular-weight molecules in nanoparticles of chitosan/poly(sodium 4-styrenesulfonate) assisted by aromatic-aromatic interactions.
- Unraveling the Alkaline Phosphatase Inhibition, Anticancer, and Antileishmanial Potential of Coumarin–Triazolothiadiazine Hybrids: Design, Synthesis, and Molecular Docking Analysis
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