Metformin: Its emerging role in oncology
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Summary
Encouraging experimental data supporting the anti-cancer effects of metformin urgently require further clinical studies in order to establish its use as a synergistic therapy targeting the AMPK/mTOR signaling pathway.
- Type
- article
- Published
- 2011-01-01
- Cited by
- 55
- References
- 86
- Access
- Open access
- OpenAlex
- https://openalex.org/W21349801
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4715437
Keywords
Humanities, Philosophy
References
- Diabetes mellitus as a risk factor for pancreatic cancer. A meta-analysis.
- The AMP-activated protein kinase cascade--a unifying system for energy control.
- Dysregulation of the TSC-mTOR pathway in human disease
- Selenium regulates cyclooxygenase-2 and extracellular signal-regulated kinase signaling pathways by activating AMP-activated protein kinase in colon cancer cells.
- Autophagy in aging and in neurodegenerative disorders
- Chronic Anovulation Syndrome and Associated Neoplasia
- Postload plasma glucose concentration and 27-year prostate cancer mortality (United States)
- Electrical stimulation inactivates muscle acetyl-CoA carboxylase and increases AMP-activated protein kinase.
- Medical Management of Hyperglycemia in Type 2 Diabetes: A Consensus Algorithm for the Initiation and Adjustment of Therapy: A Consensus Statement of the American Diabetes Association and the European Association for the Study of Diabetes
- Metformin and cancer.
- Metformin and rapamycin have distinct effects on the AKT pathway and proliferation in breast cancer cells
- Increased Cancer-Related Mortality for Patients With Type 2 Diabetes Who Use Sulfonylureas or Insulin
- Management of cellular energy by the AMP‐activated protein kinase system
- AMP-activated protein kinase-dependent and -independent mechanisms underlying in vitro antiglioma action of compound C.
- Inhibition of adenosine monophosphate-activated protein kinase induces apoptosis in multiple myeloma cells
- Metformin inhibits breast cancer cell growth, colony formation and induces cell cycle arrest in vitro
- Association between diabetes mellitus and adverse characteristics of breast cancer at presentation.
- The LKB1 tumor suppressor negatively regulates mTOR signaling.
- In vivo metformin treatment ameliorates insulin resistance: evidence for potentiation of insulin-induced translocation and increased functional activity of glucose transporters in obese (fa/fa) Zucker rat adipocytes.
- Obligatory role of membrane events in the regulatory effect of metformin on the respiratory chain function.
Cited by
- Insulin therapy in diabetes and cancer risk: Current understanding and implications for future study
- Metformin Is Associated with a Favorable Outcome in Diabetic Patients with Cervical Lymph Node Metastasis of Differentiated Thyroid Cancer
- Estado del arte: metformina, cáncer y leucemia
- Metformin Ameliorates Inflammatory Bowel Disease by Suppression of the STAT3 Signaling Pathway and Regulation of the between Th17/Treg Balance
- Type 2 diabetes mellitus and obesity are independent risk factors for poor outcome in patients with high-grade glioma
- Effect of the AMP-Kinase Modulators AICAR, Metformin and Compound C on Insulin Secretion of INS-1E Rat Insulinoma Cells under Standard Cell Culture Conditions
- Incretins and thiazolidinediones in glucose homeostasis and cancer: role of common polymorphisms.
- [Metformin as a key to alternative activation of microglia?].
- AMPK activation—protean potential for boosting healthspan
- Metformin kills and radiosensitizes cancer cells and preferentially kills cancer stem cells
- Metformin Use Among Individuals at Risk for Type 2 Diabetes
- Le parcours accidenté de la metformine : de l’ombre à la lumière !
- Metformin interacts with AMPK through binding to γ subunit
- Regulation of Hyaluronan Synthesis in Vascular Diseases and Diabetes
- Aortic intimal sarcoma: report of two cases with immunohistochemical analysis for pathogenesis.
- The Potential Molecular Therapeutic Approach in Targeting Ovarian Clear Cell Carcinoma
- Metformin potentiates rapamycin and cisplatin in gastric cancer in mice
- In Vitro Screening for Drug Repositioning
- Type 2 diabetes: the evolution of a disease
- Metformin: An Inhibitor of mTORC1 Signaling
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