Detection of chiral defects in crystalline organic solids using solid-state NMR spectroscopy.
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Summary
It is shown that it is possible to identify and quantitate the crystallographic locations of small amounts of one enantiomer (l) in the presence of predominantly the opposite D-enantiomer using solid-state nuclear magnetic resonance (NMR) spectroscopy.
- Type
- article
- Published
- 2011-05-01
- Cited by
- 8
- References
- 38
- OpenAlex
- https://openalex.org/W21280054
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25898997
Keywords
Forestry, Geography
References
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- Enantiomers, Racemates, and Resolutions
- Solid-state NMR spectroscopy
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- Separation of racemate from excess enantiomer of chiral nonracemic compounds via density gradient ultracentrifugation.
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- Temperature Dependence of 207 Pb MAS Spectra of Solid Lead Nitrate. An Accurate, Sensitive Thermometer for Variable-Temperature MAS
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- Total suppression of sidebands in CPMAS C-13 NMR
- Assuring quality of drugs by monitoring impurities.
- Enantioenrichment by Crystallization
- Locating the impurity in doped crystals using isotopic double labelling and a column “flow-through” dissolution cell: adipic acid doped with oleic acid
- Proton‐enhanced NMR of dilute spins in solids
- Racemic species of sodium ibuprofen: characterization and polymorphic relationships.
- Structural analysis of 5-fluorouracil and thymine solid solutions
- Solid-state pharmaceutical chemistry
- Determination of the optical purity of ibuprofen using X-ray powder diffraction.
- The 'structural purity' of molecular solids : An elusive concept?
- Proton NMR study of the intimacy of mixing in a hydrogen-bonded blend of polystyrene and poly(butyl methacrylate)
Cited by
- Solid‐State NMR Spectroscopy in Drug Design and Discovery
- Effect of enantiomeric ratio and preparation method on proline crystal form
- A vibrational circular dichroism (VCD) methodology for the measurement of enantiomeric excess in chiral compounds in the solid phase and for the complementary use of NMR and VCD techniques in solution: the camphor case.
- Three-Dimensional NMR Spectroscopy of Fluorinated Pharmaceutical Solids under Ultrafast Magic Angle Spinning.
- Solid-state NMR spectroscopy in pharmaceutical sciences
- Solid‐State Nuclear Magnetic Resonance of Pharmaceutical Formulations
- Crystal Imperfections in Molecular Crystals: Physical and Chemical Consequences
- Study of Disorder by Solid‐State NMR Spectroscopy
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