Insights into nucleotide recognition by cell division protein FtsZ from a mant-GTP competition assay and molecular dynamics.
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Summary
The methods permit testing of FtsZ inhibitors targeting its nucleotide site, as well as compounds from virtual screening of large synthetic libraries, and give insight into the Ftsz-nucleotide interactions, which could be useful in the rational design of new inhibitors, especially GTP phosphate mimetics.
- Type
- article
- Published
- 2010-11-17
- Cited by
- 47
- References
- 60
- OpenAlex
- https://openalex.org/W21058659
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:12873401
Keywords
Antioxidant, Endogeny, Medicine, Chemistry, Internal medicine
References
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- Calculations of binding affinity between C8-substituted GTP analogs and the bacterial cell-division protein FtsZ
- Tubulin and FtsZ form a distinct family of GTPases
- Aqueous solubilities and enthalpies of solution of adenine and guanine
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- Insight into the dynamic interaction between different flavonoids and bovine serum albumin using molecular dynamics simulations and free energy calculations
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- Comparison of Small Molecule Inhibitors of the Bacterial Cell Division Protein FtsZ and Identification of a Reliable Cross-Species Inhibitor
- Interactions of bacterial cell division protein FtsZ with C8-substituted guanine nucleotide inhibitors. A combined NMR, biochemical and molecular modeling perspective.
- Bacterial cell division proteins as antibiotic targets.
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- New interfacial microtubule inhibitors of marine origin, PM050489/PM060184, with potent antitumor activity and a distinct mechanism.
- Novel inhibitor discovery and the conformational analysis of inhibitors of listeriolysin O via protein-ligand modeling
- Independence between GTPase active sites in the Escherichia coli cell division protein FtsZ
- Insights into the specific binding site of adenosine to the Stx2, the protein toxin from Escherichia coli O157:H7 using molecular dynamics simulations and free energy calculations
- Structural and energetic analysis to provide insight residues of CYP2C9, 2C11 and 2E1 involved in valproic acid dehydrogenation selectivity.
- Targeting the assembly of bacterial cell division protein FtsZ with small molecules.
- Influence of GTP/GDP and magnesium ion on the solvated structure of the protein FtsZ: a molecular dynamics study
- Probing the conformational flexibility of monomeric FtsZ in GTP-bound, GDP-bound, and nucleotide-free states.
- Hybridization Properties of RNA Containing 8-Methoxyguanosine and 8-Benzyloxyguanosine
- Baicalin protects mice from Staphylococcus aureus pneumonia via inhibition of the cytolytic activity of α-hemolysin.
- Synthetic inhibitors of bacterial cell division targeting the GTP-binding site of FtsZ.
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