Pigment epithelium-derived factor (PEDF) is one of the most abundant proteins secreted by human adipocytes and induces insulin resistance and inflammatory signaling in muscle and fat cells
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Summary
PEDF is one of the most abundant adipokines and its secretion is inversely regulated by insulin and hypoxia, which could have an important role in diabetes and obesity-related disorders.
- Type
- article
- Published
- 2011-06-01
- Cited by
- 155
- References
- 53
- OpenAlex
- https://openalex.org/W20938440
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:8416328
Keywords
Humanities, Philosophy
References
- Pigment epithelium-derived factor is an angiogenesis and lipid regulator that activates peroxisome proliferator-activated receptor alpha.
- Pigment epithelium-derived factor contributes to insulin resistance in obesity.
- Pigment epithelium-derived factor is a substrate for matrix metalloproteinase type 2 and type 9: implications for downregulation in hypoxia.
- Pigment epithelium-derived factor inhibits TNF-alpha-induced interleukin-6 expression in endothelial cells by suppressing NADPH oxidase-mediated reactive oxygen species generation.
- Pigment epithelium-derived factor inhibits neointimal hyperplasia after vascular injury by blocking NADPH oxidase-mediated reactive oxygen species generation.
- Adipose tissue as an endocrine organ.
- Regulation of pigment epithelium-derived factor production and release by retinal glial (Müller) cells under hypoxia.
- Effects of tumour necrosis factor alpha (TNFα) on glucose transport and lipid metabolism of newly-differentiated human fat cells in cell culture
- Laminin Receptor Involvement in the Anti-angiogenic Activity of Pigment Epithelium-derived Factor*♦
- Troglitazone reduces plasminogen activator inhibitor-1 expression and secretion in cultured human adipocytes
- Oleic acid and adipokines synergize in inducing proliferation and inflammatory signalling in human vascular smooth muscle cells
- Identification of a Lipase-linked Cell Membrane Receptor for Pigment Epithelium-derived Factor*
- Effect of troglitazone on tumor necrosis factor alpha and transforming growth factor beta expression and action in human adipocyte precursor cells in primary culture.
- A comparison between Sypro Ruby and ruthenium II tris (bathophenanthroline disulfonate) as fluorescent stains for protein detection in gels
- Dysregulation of the expression and secretion of inflammation-related adipokines by hypoxia in human adipocytes
- The 67 kDa laminin receptor: structure, function and role in disease.
- Inflammation, stress, and diabetes.
- Characterization of PEDF: A multi‐functional serpin family protein
- Pigment epithelium-derived factor (PEDF) as a therapeutic target in cardiovascular disease
- PEDF: a pigment epithelium-derived factor with potent neuronal differentiative activity.
Cited by
- Thrombospondin-1 Signaling Mechanisms Regulating Pigment Epithelium-Derived Factor Expression and Lipolytic Activity in Prostate Cancer
- Adipose Tissue as an Endocrine Organ: An Update on Pro-inflammatory and Anti-inflammatory Microenvironment.
- The Role of Contractile Activity in the Crosstalk between Human Skeletal Muscle Cells and Adipocytes
- Antioxidant Function of Pigment Epithelium Derived Factor in Adipose Tissue, the Prostate, and Prostate Cancer
- Role of Adipokines in the Crosstalk Between Human Adipose Tissue and Skeletal Muscle Cells
- Effect of weight loss on serum pigment epithelium‐derived factor levels
- Plasma concentration of pigment epithelium‐derived factor is closely associated with blood pressure and predicts incident hypertension in Chinese: a 10‐year prospective study
- Identificación mediante proteómica de nuevas adipoquinas y mioquinas implicadas en la obesidad
- Cord blood adipokines, neonatal anthropometrics and postnatal growth in offspring of Hispanic and Native American women with diabetes mellitus
- Elevated plasma pigment epithelium-derived factor in children with type 2 diabetes mellitus is attributable to obesity
- CILAIR-Based Secretome Analysis of Obese Visceral and Subcutaneous Adipose Tissues Reveals Distinctive ECM Remodeling and Inflammation Mediators
- Adipokines enhance oleic acid-induced proliferation of vascular smooth muscle cells by inducing CD36 expression
- Metabolic Syndrome and Insulin Resistance: Underlying Causes and Modification by Exercise Training
- Serum levels of pigment epithelium‐derived factor (PEDF) are positively associated with acanthosis nigricans in obese adolescents
- Adipokines: A treasure trove for the discovery of biomarkers for metabolic disorders
- Resveratrol-induced changes of the human adipocyte secretion profile.
- Elevated Circulating Pigment Epithelium-Derived Factor Predicts the Progression of Diabetic Nephropathy in Patients With Type 2 Diabetes
- More than a simple storage organ: Adipose tissue as a source of adipokines involved in cardiovascular disease
- Calorie restriction-induced changes in the secretome of human adipocytes, comparison with resveratrol-induced secretome effects.
- Dual regulation of adipose triglyceride lipase by pigment epithelium-derived factor: a novel mechanistic insight into progressive obesity.
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