CHL1 Is a Selective Organizer of the Presynaptic Machinery Chaperoning the SNARE Complex
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Summary
It is shown that the cell adhesion molecule CHL1 directly interacts with and regulates the activity of the synaptic chaperones Hsc70, CSP and αSGT, indicating a remarkable selectivity of a presynaptic chaperone activity for proteins of the exocytotic machinery.
- Type
- article
- Published
- 2010-08-11
- Cited by
- 57
- References
- 57
- Access
- Open access
- OpenAlex
- https://openalex.org/W20711454
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:14891087
Keywords
Desertification, Geography, Environmental protection, Environmental resource management, Environmental planning
References
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- Gene-environment interactions in mental disorders.
- Enhanced perisomatic inhibition and impaired long‐term potentiation in the CA1 region of juvenile CHL1‐deficient mice
- Tying Everything Together: The Multiple Roles of Cysteine String Protein (CSP) in Regulated Exocytosis
- Scattering by an Inhomogeneous Solid
- Cytosolic chaperones influence the fate of a toxin dislocated from the endoplasmic reticulum
- Roles of molecular chaperones in the nervous system.
- Altered expression of CHL1 by glial cells in response to optic nerve injury and intravitreal application of fibroblast growth factor‐2
- Two distinct populations of synaptic-like vesicles from rat brain.
- An enzyme that removes clathrin coats: purification of an uncoating ATPase
- Two single nucleotide polymorphisms (SNPs) in the CALL gene for association studies with IQ.
- The Neural Recognition Molecule L1 Is a Sialic Acid-binding Lectin for CD24, Which Induces Promotion and Inhibition of Neurite Outgrowth*
- Dual role of the cysteine-string domain in membrane binding and palmitoylation-dependent sorting of the molecular chaperone cysteine-string protein.
- Interaction between Constitutively Expressed Heat Shock Protein, Hsc 70, and Cysteine String Protein Is Important for Cortical Granule Exocytosis in Xenopus Oocytes*
- The adhesion molecule CHL1 regulates uncoating of clathrin-coated synaptic vesicles.
- Close homologue of adhesion molecule L1 promotes survival of Purkinje and granule cells and granule cell migration during murine cerebellar development
- A trimeric protein complex functions as a synaptic chaperone machine.
- Case-control association study of the close homologue of L1 (CHL1) gene and schizophrenia in the Chinese population.
- Close homolog of L1 modulates area-specific neuronal positioning and dendrite orientation in the cerebral cortex.
Cited by
- Synaptic cell adhesion molecules.
- Genome wide identification of regulatory networks associated with general cognitive ability using a normalized alignment free similarity measure of promoter regions
- Transcriptome-Wide Survey of Mouse CNS-Derived Cells Reveals Monoallelic Expression within Novel Gene Families
- Interaction of the Cell Adhesion Molecule CHL1 with Vitronectin, Integrins, and the Plasminogen Activator Inhibitor-2 Promotes CHL1-Induced Neurite Outgrowth and Neuronal Migration
- Loss of cell adhesion molecule CHL1 improves homeostatic adaptation and survival in hypoxic stress
- The Neural Cell Adhesion Molecule Promotes Maturation of the Presynaptic Endocytotic Machinery by Switching Synaptic Vesicle Recycling from Adaptor Protein 3 (AP-3)- to AP-2-Dependent Mechanisms
- Development of Cortical GABAergic Innervation
- L1CAM increases MAP2 expression via the MAPK pathway to promote neurite outgrowth.
- Copy Number Variants in Extended Autism Spectrum Disorder Families Reveal Candidates Potentially Involved in Autism Risk
- Duplications in ADHD patients harbour neurobehavioural genes that are co‐expressed with genes associated with hyperactivity in the mouse
- Copy number variants and infantile spasms: evidence for abnormalities in ventral forebrain development and pathways of synaptic function
- SGTA: A New Player in the Molecular Co-Chaperone Game
- Copy number variant study of bipolar disorder in Canadian and UK populations implicates synaptic genes
- Lipid Raft-dependent Endocytosis of Close Homolog of Adhesion Molecule L1 (CHL1) Promotes Neuritogenesis*
- Immobilized Pool of NCAM180 in the Postsynaptic Membrane Is Homeostatically Replenished by the Flux of NCAM180 from Extrasynaptic Regions*
- The Neural Cell Adhesion Molecule (NCAM) Associates with and Signals through p21-Activated Kinase 1 (Pak1)
- Age‐dependent loss of parvalbumin‐expressing hippocampal interneurons in mice deficient in CHL1, a mental retardation and schizophrenia susceptibility gene
- NCAM/spectrin complex disassembly results in PSD perforation and postsynaptic endocytic zone formation.
- Kinesin-1 promotes post-Golgi trafficking of NCAM140 and NCAM180 to the cell surface
- Surface N-glycoproteome patterns reveal key proteins of neuronal differentiation.
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