The Clock Genes Period 2 and Cryptochrome 2 Differentially Balance Bone Formation
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Summary
Cry2 and Per2 affect distinct pathways in the regulation of bone volume with Cry2 influencing mostly the osteoclastic cellular component of bone and Per2 acting on osteoblast parameters.
- Type
- article
- Published
- 2010-07-12
- Cited by
- 119
- References
- 39
- Access
- Open access
- OpenAlex
- https://openalex.org/W20634945
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:16383651
Keywords
Computer science
References
- The mPer2 gene encodes a functional component of the mammalian circadian clock
- All's well that ends dead
- Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms
- Bone remodeling, energy metabolism, and the molecular clock.
- Local communication on and within bone controls bone remodeling.
- Lack of food anticipation in Per2 mutant mice.
- Skeletal remodeling in health and disease
- Circadian Oscillation of Gene Expression in Murine Calvarial Bone
- The 4th Dimension and Adult Stem Cells: Can Timing Be Everything?
- Rescue of the Skeletal Phenotype of Vitamin D Receptor-Ablated Mice in the Setting of Normal Mineral Ion Homeostasis: Formal Histomorphometric and Biomechanical Analyses1.
- Coordination of circadian timing in mammals
- Circadian mechanisms in murine and human bone marrow mesenchymal stem cells following dexamethasone exposure.
- Disruption of mCry2 restores circadian rhythmicity in mPer2 mutant mice.
- Central control of bone remodeling by neuromedin U
- Neuromedin U directly stimulates growth of cultured rat calvarial osteoblast-like cells acting via the NMU receptor 2 isoform.
- RelA/p65 promotes osteoclast differentiation by blocking a RANKL-induced apoptotic JNK pathway in mice.
- Low reproductive success in Per1 and Per2 mutant mouse females due to accelerated ageing?
- Systematic assessment of the human osteoblast transcriptome in resting and induced primary cells.
- Dissociation between bone resorption and bone formation in osteopenic transgenic mice.
- Clock-cancer connection in Non-Hodgkin’s Lymphoma: a genetic association study and pathway analysis of the circadian gene Cryptochrome 2
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- Tissue regeneration: Impact of sleep on stem cell regenerative capacity.
- The Circadian Clock in Cancer Development and Therapy
- Characterization of the Circadian Properties of Runt-related Transcription Factor 2 (Runx2) and its Role in the Suprachiasmatic Nucleus
- Region-specific effects of restricted feeding on daily rhythms of the clock proteins, Period1 and Period2, in the forebrain of the male Wistar rat
- Investigating Age-Dependent Arthropathy in a Circadian Mutant Mouse Model: A Dissertation
- Circadian systems biology: When time matters
- Obstructive sleep apnea and metabolic bone disease: Insights in to the relationship between bone and sleep
- Environmental Disruption of Circadian Rhythm Predisposes Mice to Osteoarthritis-Like Changes in Knee Joint
- Overexpression of the Circadian Clock Gene Rev-erbα Affects Murine Bone Mesenchymal Stem Cell Proliferation and Osteogenesis
- Tracking Circadian Rhythms of Bone Mineral Deposition in Murine Calvarial Organ Cultures
- An essential role for the circadian-regulated gene Nocturnin in osteogenesis: the importance of local timekeeping in skeletal homeostasis
- Melatonin effects on bone: potential use for the prevention and treatment for osteopenia, osteoporosis, and periodontal disease and for use in bone‐grafting procedures
- The Transcription Factor Runx2 Is under Circadian Control in the Suprachiasmatic Nucleus and Functions in the Control of Rhythmic Behavior
- Human mesenchymal stem cell differentiation to the osteogenic or adipogenic lineage is regulated by AMP‐activated protein kinase
- The daily rhythm of mice
- Gremlin-2 is a BMP antagonist that is regulated by the circadian clock
- The Tick Tock of Odontogenesis
- Prolonged Bioluminescence Monitoring in Mouse Ex Vivo Bone Culture Revealed Persistent Circadian Rhythms in Articular Cartilages and Growth Plates
- Circadian gene variants in cancer
- Circadian Rhythms Regulate Amelogenesis
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