α-Conotoxin AuIB Isomers Exhibit Distinct Inhibitory Mechanisms and Differential Sensitivity to Stoichiometry of α3β4 Nicotinic Acetylcholine Receptors*
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Summary
In conclusion, the two isomers of AuIB differ in their inhibitory mechanisms such that AuIB(ribbon) inhibits only LS α3β4 nAChRs competitively, whereas Auib(globular) inhibits α3 β4 n aChRs irrespective of receptor stoichiometry, primarily by a non-competitive mechanism.
- Type
- article
- Published
- 2010-05-13
- Cited by
- 61
- References
- 43
- OpenAlex
- https://openalex.org/W20466726
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25214071
Keywords
Computer science
References
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Cited by
- Optimal Cleavage and Oxidative Folding of α-Conotoxin TxIB as a Therapeutic Candidate Peptide
- Stabilization of α-Conotoxin AuIB: Influences of Disulfide Connectivity and Backbone Cyclization
- Discovery of a new subclass of α-conotoxins in the venom of Conus australis.
- Determination of the α-conotoxin Vc1.1 binding site on the α9α10 nicotinic acetylcholine receptor.
- Structure-activity studies of 7-heteroaryl-3-azabicyclo[3.3.1]non-6-enes: a novel class of highly potent nicotinic receptor ligands.
- Alanine Scan of α-Conotoxin RegIIA Reveals a Selective α3β4 Nicotinic Acetylcholine Receptor Antagonist*
- Presence of multiple binding sites on α9α10 nAChR receptors alludes to stoichiometric dependent action of the α-conotoxin, Vc1.1
- Conotoxins Targeting Nicotinic Acetylcholine Receptors: An Overview
- RegIIA: an α4/7-conotoxin from the venom of Conus regius that potently blocks α3β4 nAChRs.
- Therapeutic potential of cone snail venom peptides (conopeptides).
- Discovery, synthesis and development of structure-activity relationships of Conotoxins
- Nicotinic acetylcholine receptors: from basic science to therapeutics.
- Actions of α-conotoxins on neuronal nicotinic acetylcholine receptors and synaptic transmission in rat parasympathetic ganglia
- Physical and virtual screening methods for marine toxins and drug discovery targeting nicotinic acetylcholine receptors
- Function of Human α3β4α5 Nicotinic Acetylcholine Receptors Is Reduced by the α5(D398N) Variant*
- Recent advances in understanding nicotinic receptor signaling mechanisms that regulate drug self-administration behavior
- Identifying Key Amino Acid Residues That Affect α-Conotoxin AuIB Inhibition of α3β4 Nicotinic Acetylcholine Receptors*
- Conus Venom Peptide Pharmacology
- Scrambling of disulfide bond scaffolds in neurotoxin AuIB: A molecular dynamics simulation study
- Structure-Activity Studies of Cysteine-Rich α-Conotoxins that Inhibit High-Voltage-Activated Calcium Channels via GABA(B) Receptor Activation Reveal a Minimal Functional Motif.
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