Small-molecule ligands of GD2 ganglioside, designed from NMR studies, exhibit induced-fit binding and bioactivity.
Explore this paper's citation graph
Summary
Three small-molecule cyclic peptide ligands that bind to GD2 selectively were designed and showed an induced-fit binding mechanism, furthering the concept of rationally designing ligands for carbohydrate targets, and may be expanded to other clinically relevant gangliosides.
- Type
- article
- Published
- 2010-02-26
- Cited by
- 12
- References
- 43
- Access
- Open access
- OpenAlex
- https://openalex.org/W20189108
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:41220924
Keywords
Unit (ring theory), Computer science, Mathematics, Mathematics education
References
- Aggregative properties of gangliosides in solution.
- NMRPipe: A multidimensional spectral processing system based on UNIX pipes
- The effect of relaxation on the epitope mapping by saturation transfer difference NMR.
- Bifunctional catalysis of proton transfer at an antibody active site.
- Loops and Secondary Structure Mimetics: Development and Applications in Basic Science and Rational Drug Design
- Pathogenesis of the neurotoxicity caused by anti-GD2 antibody therapy.
- Molecular Mechanical and Molecular Dynamic Simulations of Glycoproteins and Oligosaccharides. 1. GLYCAM_93 Parameter Development
- Tenascin‐R interferes with integrin‐dependent oligodendrocyte precursor cell adhesion by a ganglioside‐mediated signalling mechanism
- Complete relaxation and conformational exchange matrix (CORCEMA) analysis of intermolecular saturation transfer effects in reversibly forming ligand-receptor complexes.
- Pulsed-Field Gradient and Saturation Transfer Difference NMR Study of Enkephalins in the Ganglioside GM1 Micelle
- A Single Bifunctional UDP-GlcNAc/Glc 4-Epimerase Supports the Synthesis of Three Cell Surface Glycoconjugates in Campylobacter jejuni*
- Saturation transfer difference nuclear magnetic resonance study on the specific binding of ligand to protein.
- Chemoenzymatic synthesis of 2-azidoethyl-ganglio-oligosaccharides GD3, GT3, GM2, GD2, GT2, GM1, and GD1a.
- Identification of a human neuroectodermal tumor antigen (OFA-I-2) as ganglioside GD2.
- Interaction and structural study of kinin peptide bradykinin and ganglioside monosialylated 1 micelle
- Dictionary of protein secondary structure: Pattern recognition of hydrogen‐bonded and geometrical features
- Automatic atom type and bond type perception in molecular mechanical calculations.
- Disialoganglioside Directed Immunotherapy of Neuroblastoma
- Role of tumor-associated gangliosides in cancer progression.
- Glycosphingolipid antigens and cancer therapy.
Cited by
- Anti-GD2 Etoposide-Loaded Immunoliposomes for the Treatment of GD2 Positive Tumors
- Ligands Binding to Cell Surface Ganglioside GD2 Cause Src-Dependent Activation of N-Methyl-D-Aspartate Receptor Signaling and Changes in Cellular Morphology
- Binding sugars: from natural lectins to synthetic receptors and engineered neolectins.
- Disialoganglioside GD2 as a therapeutic target for human diseases
- Toward bioinspired galectin mimetics: identification of ligand-contacting peptides by proteolytic-excision mass spectrometry.
- Glycosylation of Glycolipids in Cancer: Basis for Development of Novel Therapeutic Approaches
- Analysis and optimization of interactions between peptides mimicking the GD2 ganglioside and the monoclonal antibody 14G2a.
- Rational design of peptide ligands against a glycolipid by NMR studies.
- Inhibition of CD45 Phosphatase Activity Induces Cell Cycle Arrest and Apoptosis of CD45+ Lymphoid Tumors Ex Vivo and In Vivo
- Vaccination with Tumor-Ganglioside Glycomimetics Activates a Selective Immunity that Affords Cancer Therapy.
- Conformational Changes in Tyrosine 11 of Neurotensin Are Required to Activate the Neurotensin Receptor 1.
- GD2 Identifies Cancer Stemness in Glioblastoma and Phytoalexin Library Screen Identifies Potential Novel Natural Inhibitors
Related papers
No related papers recorded.