Differential contribution of the m7G-cap to the 5′ end-dependent translation initiation of mammalian mRNAs

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Summary

It is not mandatory to invoke the IRES hypothesis, at least for some mRNAs, to explain their preferential translation when eIF4E is partially inactivated, because in cultured cells or cytoplasmic extracts both the level of stimulation with the cap and the overall translation activity do not correlate with the cumulative energy of the secondary structure of the tested 5′ UTRs.

Type
article
Published
2009-08-20
Cited by
107
References
62
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Open access

Keywords

Computer science

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