Differential contribution of the m7G-cap to the 5′ end-dependent translation initiation of mammalian mRNAs
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Summary
It is not mandatory to invoke the IRES hypothesis, at least for some mRNAs, to explain their preferential translation when eIF4E is partially inactivated, because in cultured cells or cytoplasmic extracts both the level of stimulation with the cap and the overall translation activity do not correlate with the cumulative energy of the secondary structure of the tested 5′ UTRs.
- Type
- article
- Published
- 2009-08-20
- Cited by
- 107
- References
- 62
- Access
- Open access
- OpenAlex
- https://openalex.org/W19696074
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:20827
Keywords
Computer science
References
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Cited by
- Identification of Cardiac Glycoside Molecules as Inhibitors of c-Myc IRES-Mediated Translation
- Translational Regulation of Bovine Casein
- The 5′-untranslated region of p16INK4a melanoma tumor suppressor acts as a cellular IRES, controlling mRNA translation under hypoxia through YBX1 binding
- Cis-Acting Sequence Elements and Upstream Open Reading Frame in Mouse Utrophin-A 5'-UTR Repress Cap-Dependent Translation
- Elucidating The Regulatory Mechanisms Of The Mammalian Target Of Rapamycin Complex 1 (Mtorc1) In Protein Homeostasis
- Targeting Translation Dependence in Cancer
- Alternative Ways to Think about Cellular Internal Ribosome Entry*
- The translational response of the human mdm2 gene in HEK293T cells exposed to rapamycin: a role for the 5′-UTRs
- Design of Targeted B Cell Killing Agents
- Cellular IRES-mediated translation
- Cap- and IRES-independent scanning mechanism of translation initiation as an alternative to the concept of cellular IRESs
- Glycyl-tRNA synthetase specifically binds to the poliovirus IRES to activate translation initiation
- In vitro activity of human translation initiation factor eIF4B is not affected by phosphomimetic amino acid substitutions S422D and S422E.
- Secondary RNA structure and nucleotide specificity contribute to internal initiation mediated by the human tau 5′ leader
- Length variants of the 5′ untranslated region of p53 mRNA and their impact on the efficiency of translation initiation of p53 and its N-truncated isoform ΔNp53
- Translation initiation is driven by different mechanisms on the HIV-1 and HIV-2 genomic RNAs.
- Translation initiation mediated by RNA looping
- Translation initiation in eukaryotes: Versatility of the scanning model
- Archaeal translation initiation factor aIF2 can substitute for eukaryotic eIF2 in ribosomal scanning during mammalian 48S complex formation.
- mTOR Inhibition by Everolimus in Childhood Acute Lymphoblastic Leukemia Induces Caspase-Independent Cell Death
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