Fusion processing of itraconazole solid dispersions by kinetisol dispersing: a comparative study to hot melt extrusion.
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Summary
KinetiSol Dispersing was shown to be a viable manufacturing process for the production of pharmaceutical solid dispersions, providing benefits over conventional techniques including: enhanced mixing for improved homogeneity and reduced processing times.
- Type
- dissertation
- Published
- 2010-03-01
- Cited by
- 68
- References
- 41
- OpenAlex
- https://openalex.org/W19681106
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:6226881
Keywords
Medicine, Humanities, Art
References
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- Characterization of the interaction of 2-hydroxypropyl-beta-cyclodextrin with itraconazole at pH 2, 4, and 7.
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Cited by
- Hot Melt Extrudates Formulated Using Design Space: One Simple Process for Both Palatability and Dissolution Rate Improvement.
- Interactions between drugs and polymers influencing hot melt extrusion
- Thermal characterization and compatibility studies of itraconazole and excipients for development of solid lipid nanoparticles
- Applications of KinetiSol dispersing for the production of plasticizer free amorphous solid dispersions.
- Preparation and characterization of fusion processed solid dispersions containing a viscous thermally labile polymeric carrier.
- Solubility and dissolution enhancement strategies: current understanding and recent trends*
- Hot-melt extrusion technology and pharmaceutical application.
- The use of inorganic salts to improve the dissolution characteristics of tablets containing Soluplus®-based solid dispersions.
- Ditosylate Salt of Itraconazole and Dissolution Enhancement Using Cyclodextrins
- Solid dispersions, Part II: new strategies in manufacturing methods for dissolution rate enhancement of poorly water-soluble drugs
- Increased dissolution and oral absorption of itraconazole/Soluplus extrudate compared with itraconazole nanosuspension.
- Enhancing bioavailability through thermal processing.
- Solid Dispersion as a Strategy to Improve Drug Bioavailability
- Thermal processing of a poorly water-soluble drug substance exhibiting a high melting point: the utility of KinetiSol® Dispersing.
- Assessing the performance of amorphous solid dispersions.
- Application and functional characterization of POVACOAT, a hydrophilic co-polymer poly(vinyl alcohol/acrylic acid/methyl methacrylate) as a hot-melt extrusion carrier
- The use of amorphous solid dispersions: A formulation strategy to overcome poor solubility and dissolution rate.
- Fusion production of solid dispersions containing a heat-sensitive active ingredient by hot melt extrusion and Kinetisol dispersing.
- Dissolution Enhancement of a Drug Exhibiting Thermal and Acidic Decomposition Characteristics by Fusion Processing: A Comparative Study of Hot Melt Extrusion and KinetiSol® Dispersing
- Current trends and future perspectives of solid dispersions containing poorly water-soluble drugs.
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