Molecular determinants of β‐carboline inhibition of the glycine receptor
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Summary
Results which define the orientation of the bound β‐carbolines were supported by molecular docking simulations, and may be relevant to understanding the mechanism β‐carboline of binding to GABA type A receptors where they are potent pharmacological probes.
- Type
- article
- Published
- 2009-09-01
- Cited by
- 11
- References
- 38
- OpenAlex
- https://openalex.org/W19619142
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:23976028
Keywords
Genetics, Autism spectrum disorder, Autism, GABAA receptor, Medicine
References
- Characterization of a glycine receptor domain that controls the binding and gating mechanisms of the β‐amino acid agonist, taurine
- The glycinergic control of spinal pain processing
- Identification of a New Ligand Binding Domain in the α1 Subunit of the Inhibitory Glycine Receptor
- Glycine receptors: a new therapeutic target in pain pathways.
- The unique extracellular disulfide loop of the glycine receptor is a principal ligand binding element.
- Selective Antagonism of GABAA Receptor Subtypes: An In Vivo Approach to Exploring the Therapeutic and Side Effects of Benzodiazepine–Type Drugs
- Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors
- Distinct agonist- and antagonist-binding sites on the glycine receptor.
- Structural Requirements for Ligand Interactions at the Benzodiazepine Recognition Site of the GABAA Receptor
- Energetics of protein-protein interactions: analysis of the barnase-barstar interface by single mutations and double mutant cycles.
- Revealing the architecture of a K+ channel pore through mutant cycles with a peptide inhibitor.
- Behavioral differences between subgroups of rats with high and low threshold to clonic convulsions induced by DMCM, a benzodiazepine inverse agonist.
- Plant hallucinogens: springboards for psychotherapeutic drug discovery.
- DISTRIBUTION OF GABAA AND GLYCINE RECEPTORS IN THE MAMMALIAN RETINA
- Molecular structure and function of the glycine receptor chloride channel.
- Diversity of glycine receptors in the mouse retina: Localization of the α4 subunit
- Identification of amino acid residues responsible for the alpha5 subunit binding selectivity of L-655,708, a benzodiazepine binding site ligand at the GABA(A) receptor.
- Gephyrin: where do we stand, where do we go?
- Structural features controlling the binding of beta-carbolines to the benzodiazepine receptor.
- Mutation of glycine receptor subunit creates beta-alanine receptor responsive to GABA.
Cited by
- Stimulation, protection and regeneration of dopaminergic neurons by 9-methyl-β-carboline: a new anti-Parkinson drug?
- Phosphorylation of α3 glycine receptors induces a conformational change in the glycine-binding site.
- Ayahuasca: Psychological and Physiologic Effects, Pharmacology and Potential Uses in Addiction and Mental Illness
- Role of primary metabolites in plant defense against pathogens.
- Modulators of the inhibitory glycine receptor.
- Secondary metabolites as plant defensive strategy: a large role for small molecules in the near root region
- Role of secondary metabolites in plant defense against pathogens.
- The current state of ayahuasca research in animal models: A systematic review.
- Role of Plant Secondary Metabolites in Defence and Transcriptional Regulation in Response to Biotic Stress
- The evolutionary trajectories of specialized metabolites towards antiviral defense system in plants
- Beyond Survival: The Role of Secondary Metabolites in Plant Defense Mechanisms
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