Cardiac c‐kit+AT2+ Cell Population is Increased in Response to Ischemic Injury and Supports Cardiomyocyte Performance
Explore this paper's citation graph
Summary
In vivo AT2 receptor stimulation led to an increased c‐kit+AT2+ cell population in the infarcted myocardium and reduced apoptosis of cardiomyocytes in rats with acute myocardial infarction, suggesting that cardiac c‐Kit+AT 2+ cellpopulation exists and increases after acute ischemic injury.
- Type
- article
- Published
- 2009-10-01
- Cited by
- 70
- References
- 39
- Access
- Open access
- OpenAlex
- https://openalex.org/W19591228
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:2662531
Keywords
Chromogranin A, Immunohistochemistry, Endocrine system, Androgen, Hyperplasia
References
- Angiotensin type 2 receptors are reexpressed by cardiac fibroblasts from failing myopathic hamster hearts and inhibit cell growth and fibrillar collagen metabolism.
- Expression of angiotensin AT(1) and AT(2) receptors in adult rat cardiomyocytes after myocardial infarction. A single-cell reverse transcriptase-polymerase chain reaction study.
- A simple technique for quantifying apoptosis in 96-well plates
- Expression cloning of type 2 angiotensin II receptor reveals a unique class of seven-transmembrane receptors
- Deletion of Angiotensin II Type 2 Receptor Attenuates Protective Effects of Bone Marrow Stromal Cell Treatment on Ischemia–Reperfusion Brain Injury in Mice
- Inhibition of transcription factor GATA-4 expression blocks in vitro cardiac muscle differentiation
- Angiotensin II type 2 receptor stimulation increases the rate of NG108-15 cell migration via actin depolymerization.
- The Ki‐67 protein: From the known and the unknown
- Apoptosis in human acute myocardial infarction.
- Angiotensin II induces apoptosis of adult ventricular myocytes in vitro.
- The Angiotensin II Type 2 (AT2) Receptor Promotes Axonal Regeneration in the Optic Nerve of Adult Rats
- Developmental patterning of the cardiac atrioventricular canal by Notch and Hairy-related transcription factors
- Cellular Cardiomyoplasty: Improvement of Left Ventricular Function Correlates with the Release of Cardioactive Cytokines
- Design, synthesis, and biological evaluation of the first selective nonpeptide AT2 receptor agonist.
- The angiotensin II type 2 (AT2) receptor antagonizes the growth effects of the AT1 receptor: gain-of-function study using gene transfer.
- Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes
- Adult cardiac stem cells are multipotent and support myocardial regeneration.
- Intense myocyte formation from cardiac stem cells in human cardiac hypertrophy
- Cardioprotective c-kit+ cells are from the bone marrow and regulate the myocardial balance of angiogenic cytokines.
- Effects of angiotensin-converting enzyme inhibitors and angiotensin II type 1 receptor antagonists in rats with heart failure. Role of kinins and angiotensin II type 2 receptors.
Cited by
- Sublethal Caspase Activation Promotes Generation of Cardiomyocytes from Embryonic Stem Cells
- Cell-Specific Protective Signaling Induced by the Novel AT2R-Agonist NP-6A4 on Human Endothelial and Smooth Muscle Cells
- Exploiting AT2R to Improve CD117 Stem Cell Function In Vitro and In Vivo - Perspectives for Cardiac Stem Cell Therapy
- Impact of Renin-Angiotensin- and Kallikrein-Kinin Systems in Aneurysm Formation and Possible Therapeutic Implications
- The CD4+AT2R+ T cell subpopulation improves post-infarction remodelling and restores cardiac function
- Untersuchungen zur funktionellen Interaktion zwischen dem Rezeptor Mas und dem AT2-Rezeptor in primären, murinen Astrozyten
- c-Kit identifies a subpopulation of mesenchymal stem cells in adipose tissue with higher telomerase expression and differentiation potential.
- Cardiac primitive cells become committed to a cardiac fate in adult human heart with chronic ischemic disease but fail to acquire mature phenotype: genetic and phenotypic study
- Preconditioning via Angiotensin Type 2 Receptor Activation Improves Therapeutic Efficacy of Bone Marrow Mononuclear Cells for Cardiac Repair
- Trophic Actions of Bone Marrow-Derived Mesenchymal Stromal Cells for Muscle Repair/Regeneration
- Cardioprotective C-kit+ Bone Marrow Cells Attenuate Apoptosis after Acute Myocardial Infarction in Mice - In-vivo Assessment with Fluorescence Molecular Imaging
- Chronic AMD3100 Antagonism of SDF-1α-CXCR4 Exacerbates Cardiac Dysfunction and Remodeling after Myocardial Infarction
- Trop2 plays a cardioprotective role by promoting cardiac c-kit+ cell proliferation and inhibition of apoptosis in the acute phase of myocardial infarction.
- Long-Term Effects of Early Overnutrition in the Heart of Male Adult Rats: Role of the Renin-Angiotensin System
- The regenerative potential of angiotensin AT2 receptor in cardiac repair.
- Hematopoiesis leading to a diversity of dendritic antigen‐presenting cell types
- Local activation of cardiac stem cells for post-myocardial infarction cardiac repair
- MYOCARDIAL AKT: THE OMNIPRESENT NEXUS
- Angiotensin type 2 receptor in hypertensive cardiovascular disease
- Mesenchymal stromal cells affect cardiomyocyte growth through juxtacrine Notch-1/Jagged-1 signaling and paracrine mechanisms: clues for cardiac regeneration.
Related papers
No related papers recorded.