Next-generation gene targeting in the mouse for functional genomics.
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Summary
Overall trends in the large-scale mouse mutagenesis will be reviewed in this article particularly focusing on the new advancement of the next-generation gene targeting system which allows for the drastic expansion of the mutant mouse resources altogether to enhance the systematic understanding of the life.
- Type
- article
- Published
- 2009-06-30
- Cited by
- 47
- References
- 63
- Access
- Open access
- OpenAlex
- https://openalex.org/W19558788
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:22226646
Keywords
Recreation, Stewardship (theology), Active listening, Environmental stewardship, Commission
References
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- A mouse for all reasons.
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- The occurrence of two heritable types of abnormality among the descendants of X-rayed mice.
- Use of double-replacement gene targeting to replace the murine alpha-lactalbumin gene with its human counterpart in embryonic stem cells and mice
- High-throughput detection of unknown mutations by using multiplexed capillary electrophoresis with poly(vinylpyrrolidone) solution.
- Molecular characterization of ENU mouse mutagenesis and archives.
- Mutation detection using a novel plant endonuclease.
- High frequency targeting of genes to specific sites in the mammalian genome.
- ARTIFICIAL TRANSMUTATION OF THE GENE.
- Sequence-based analysis of mutagenized mice
- High-resolution genotyping by amplicon melting analysis using LCGreen.
- Gene replacement of the p53 gene with the lacZ gene in mouse embryonic stem cells and mice by using two steps of homologous recombination.
- Double replacement: strategy for efficient introduction of subtle mutations into the murine Col1a-1 gene by homologous recombination in embryonic stem cells.
- Phylogenetic conservation of a limb-specific, cis-acting regulator of Sonic hedgehog (Shh)
- A series of ENU-induced single-base substitutions in a long-range cis-element altering Sonic hedgehog expression in the developing mouse limb bud.
- An N-ethyl-N-nitrosourea-induced mutation in N-acetyltransferase 1 in mice.
- The Knockout Mouse Project
- Dose--response curve for ethylnitrosourea-induced specific-locus mutations in mouse spermatogonia.
- Regulating the p53 pathway: in vitro hypotheses, in vivo veritas
Cited by
- [Technological advances in single-cell genomic analyses].
- Mouse mutagenesis and disease models for neuropsychiatric disorders.
- ENU-induced mutant mice for a next-generation gene-targeting system.
- Human protein function prediction : application of machine learning for integration of heterogeneous data sources
- α-1,3-Galactosyltransferase Knockout Pig Induced Pluripotent Stem Cells: A Cell Source for the Production of Xenotransplant Pigs
- Phenotype-driven mouse ENU mutagenesis screens.
- Creating a “hopeful monster”: Mouse forward genetic screens
- TU3A is a novel stress-regulated protein involved in cognition and emotional behavior
- Genome-wide ENU Mutagenesis for the Discovery of Novel Male Fertility Regulators
- Dissemination of Advanced Mouse Resources and Technologies at RIKEN BioResource Center
- A colitis locus on chromosome 2 impacting the severity of early-onset disease in mice deficient in GPX1 and GPX2
- Embryo and gamete cryopreservation for genetic resources conservation of laboratory animals
- Dog Models of Naturally Occurring Cancer
- ENU-based gene-driven mutagenesis in the mouse: a next-generation gene-targeting system.
- Human germline genetic modification: scientific and bioethical perspectives.
- Validation of adequate endogenous reference genes for the normalisation of qPCR gene expression data in human post mortem tissue
- Mouse models in male fertility research.
- Family reunion--the ZIP/prion gene family.
- Recombinant retroviral production and infection of B cells.
- Defective Craniofacial Development and Brain Function in a Mouse Model for Depletion of Intracellular Inositol Synthesis*
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