PinX1 Is a Novel Microtubule-binding Protein Essential for Accurate Chromosome Segregation*
Explore this paper's citation graph
Summary
The real time imaging analyses show that suppression of PinX1 by small interference RNA abrogates faithful chromosome segregation and results in anaphase chromatid bridges in mitosis and micronuclei in interphase, suggesting an essential role of Pin X1 in chromosome stability.
- Type
- article
- Published
- 2009-06-24
- Cited by
- 48
- References
- 42
- OpenAlex
- https://openalex.org/W19553660
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25784506
Keywords
Philosophy
References
- The formation, structure, and composition of the mammalian kinetochore and kinetochore fiber.
- Human Zw10 and ROD are mitotic checkpoint proteins that bind to kinetochores
- Phospho-regulation of HsCdc14A By Polo-like Kinase 1 Is Essential for Mitotic Progression*
- Phosphorylation of HsMis13 by Aurora B Kinase Is Essential for Assembly of Functional Kinetochore*
- A Rae1-containing ribonucleoprotein complex is required for mitotic spindle assembly.
- The conserved KMN network constitutes the core microtubule-binding site of the kinetochore.
- A specific interaction between the telomeric protein Pin2/TRF1 and the mitotic spindle.
- Kinetochore microtubule dynamics and attachment stability are regulated by Hec1.
- Nucleolin functions in nucleolus formation and chromosome congression
- Self-organization of microtubules into bipolar spindles around artificial chromosomes in Xenopus egg extracts
- TTK kinase is essential for the centrosomal localization of TACC2
- Importin β Is a Mitotic Target of the Small GTPase Ran in Spindle Assembly
- The Yeast Homolog of Human PinX1 Is Involved in rRNA and Small Nucleolar RNA Maturation, Not in Telomere Elongation Inhibition*
- Characterization of a novel effect of hPinX1 on hTERT nucleolar localization.
- Visualization of a Ran-GTP Gradient in Interphase and Mitotic Xenopus Egg Extracts
- Chromokinesins: multitalented players in mitosis.
- The perichromosomal layer
- Human NUF2 Interacts with Centromere-associated Protein E and Is Essential for a Stable Spindle Microtubule-Kinetochore Attachment*
- The Microtubule-dependent Motor Centromere–associated Protein E (CENP-E) Is an Integral Component of Kinetochore Corona Fibers That Link Centromeres to Spindle Microtubules
- The spindle-assembly checkpoint in space and time
Cited by
- Dynamic Autophosphorylation of Mps1 Kinase Is Required for Faithful Mitotic Progression
- A hypothesis on the origin and evolution of tubulin.
- Alternative lengthening of telomeres: recurrent cytogenetic aberrations and chromosome stability under extreme telomere dysfunction.
- Analysis of telomere dynamics in human tissues
- PinX1: a sought-after major tumor suppressor at human chromosome 8p23
- Impact of carotid atherosclerosis loci on cardiovascular events.
- Continual Expression Throughout the Cell Cycle and Downregulation upon Adipogenic Differentiation Makes Nucleostemin a Vital Human MSC Proliferation Marker
- The 68-kDa Telomeric Repeat Binding Factor 1 (TRF1)-associated Protein (TAP68) Interacts with and Recruits TRF1 to the Spindle Pole during Mitosis*
- The nuclear scaffold protein SAF-A is required for kinetochore–microtubule attachment and contributes to the targeting of Aurora-A to mitotic spindles
- Expression and mechanism of PinX1 and telomerase activity in the carcinogenesis of esophageal epithelial cells.
- Chromatin Protein HP1α Interacts with the Mitotic Regulator Borealin Protein and Specifies the Centromere Localization of the Chromosomal Passenger Complex*
- Plk1-mediated mitotic phosphorylation of PinX1 regulates its stability.
- Decreased expression of PinX1 protein predicts poor prognosis of colorectal cancer patients receiving 5-FU adjuvant chemotherapy.
- PinX1 Localizes to Telomeres and Stabilizes TRF1 at Mitosis
- The F-box protein β-TrCP promotes ubiquitination of TRF1 and regulates the ALT-associated PML bodies formation in U2OS cells.
- PinX1 without the G-patch motif suppresses proliferation, induces senescence, but does not inhibit telomerase activity in colorectal cancer SW480 cells.
- The telomerase inhibitor PinX1 is a major haploinsufficient tumor suppressor essential for chromosome stability in mice.
- The chromosome peripheral proteins play an active role in chromosome dynamics
- The telomere/telomerase binding factor PinX1 is a new target to improve the radiotherapy effect of oesophageal squamous cell carcinomas
- The telomere/telomerase binding factor PinX1 regulates paclitaxel sensitivity depending on spindle assembly checkpoint in human cervical squamous cell carcinomas.
Related papers
No related papers recorded.