DNA polymorphisms at the BCL11A, HBS1L-MYB, and β-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease

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Summary

Genotyping additional BCL11A SNPs, HBS1L-MYB SNPs and an SNP upstream of Gγ-globin (HBG2; the XmnI polymorphism) provided a clear example of inherited common sequence variants modifying the severity of a monogenic disease.

Type
dissertation
Published
2008-08-19
Cited by
579
References
33

Keywords

Cronbach's alpha, Information and Communications Technology, Medical education, Psychology, Reliability (semiconductor)

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