Methylation status in healthy subjects with normal and high serum folate concentration.
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Summary
Serum folate concentrations in the highest quintile among healthy humans are associated with increased erythrocyte SAM and SAH concentrations, but not with SAM/SAH ratio or with methylation levels of CpG sites across the promoter region of the ec-SOD gene.
- Type
- article
- Published
- 2008-11-01
- Cited by
- 38
- References
- 40
- Access
- Open access
- OpenAlex
- https://openalex.org/W2058535104
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:10612103
Keywords
Methylation, Methylenetetrahydrofolate reductase, CpG site, Superoxide dismutase, Internal medicine
References
- Intracellular S-adenosylhomocysteine increased levels are associated with DNA hypomethylation in HUVEC
- Laboratory Methods for the Detection of Mutations and Polymorphisms in DNA
- DNA Methylation Profile of the Mouse Skeletal α-Actin Promoter during Development and Differentiation
- High sensitivity mapping of methylated cytosines.
- Brain ATP:L-methionine S-adenosyltransferase (MAT), S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH): regional distribution and age-related changes.
- Role of DNA methylation in the regulation of cell function.
- Extracellular superoxide dismutase (SOD3): tissue-specific expression, genomic characterization, and computer-assisted sequence analysis of the human EC SOD gene.
- Maintenance and regulation of DNA methylation patterns in mammals.
- Supranormal dietary folic acid supplementation: effects on methionine metabolism in weanling rats
- Methylation of the mouse Xist gene in sperm and eggs correlates with imprinted Xist expression and paternal X–inactivation
- Feedback inhibition of methylene-tetrahydrofolate reductase in rat liver by S-adenosylmethionine.
- Lack of effect of diet-induced hypomethylation on endothelium-dependent relaxation in rats.
- Epigenetics and epimutagens: some new perspectives on cancer, germ line effects and endocrine disrupters.
- Folic acid treatment increases homocysteine remethylation and methionine transmethylation in healthy subjects.
- Impaired plasma nitric oxide availability and extracellular superoxide dismutase activity in healthy humans with advancing age.
- The Effect of Folate Fortification of Cereal-Grain Products on Blood Folate Status, Dietary Folate Intake, and Dietary Folate Sources among Adult Non-Supplement Users in the United States
- Linkage disequilibrium of MTHFR genotypes 677C/T-1298A/C in the German population and association studies in probands with neural tube defects(NTD).
- Sensitivity of markers of DNA stability and DNA repair activity to folate supplementation in healthy volunteers
- Environment, diet and CpG island methylation: epigenetic signals in gastrointestinal neoplasia.
- Metabolic regulatory properties of S-adenosylmethionine and S-adenosylhomocysteine
Cited by
- The origin of congenital heart defects and the epigenetic programming of the healthy child
- Epigenetics and obesity.
- Detection of S‐adenosylhomocysteine and methylation index in blood by capillary electrophoresis
- Epigenetic Epidemiology: Promises for Public Health Research
- Congenital heart defects and biomarkers of methylation in children: a case–control study
- Rett syndrome: Neurologic and metabolic aspects
- Characterisation of CpG methylation in the upstream control region of mouse Nat2: evidence for a gene-environment interaction in a polymorphic gene implicated in folate metabolism.
- Folate and DNA Methylation
- Methylation potential associated with diet, genotype, protein, and metabolite levels in the Delta Obesity Vitamin Study
- A higher degree of LINE-1 methylation in peripheral blood mononuclear cells, a one-carbon nutrient related epigenetic alteration, is associated with a lower risk of developing cervical intraepithelial neoplasia
- S-adenosylmethionine and S-adenosylhomocysteine in plasma and cerebrospinal fluid in Rett syndrome and the effect of folinic acid supplementation
- Regulation of Superoxide Dismutase Genes: Implications in Diseases
- Examining the folate status of Canadians: An analysis of the Canadian Health Measures Survey to assess and guide folate policies.
- Effect of cadmium on cortisol production and 11beta-hydroxysteroid dehydrogenase 2 expression by cultured human choriocarcinoma cells (JEG-3).
- [Flour fortification with folic acid in Chile. Unintended consequences].
- Superoxide dismutase 3 is induced by antioxidants, inhibits oxidative DNA damage and is associated with inhibition of estrogen-induced breast cancer.
- Epigenetic and phenotypic changes result from a continuous pre and post natal dietary exposure to phytoestrogens in an experimental population of mice
- The MTHFR C677T polymorphism and global DNA methylation in oral epithelial cells
- Effects of Obesity on Serum Concentration of Methylation and Oxidative/ Nitrosative Stress Metabolites Following DMBA Treatment of Female Zucker Rats
- THE INFLUENCE OF BODY MASS INDEX ON GLOBAL DNA METHYLATION LEVELS IN BLOOD LEUKOCYTES
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