Additive Inhibitory Effect of Experimentally Induced Hepatic Cirrhosis by Agonists of Peroxisome Proliferator Activator Receptor γ and Retinoic Acid Receptor
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Summary
The combination of PPAR-γ and RAR agonists demonstrated an additive effect in the inhibition of TAA-induced hepatic fibrosis, due to inhibition of HSC proliferation and reduction of profibrotic TGFβ1 and proinflammatory TNFα.
- Type
- article
- Published
- 2009-02-01
- Cited by
- 23
- References
- 43
- OpenAlex
- https://openalex.org/W18594976
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:24377711
Keywords
Petroleum, Vanadium, Petroleum industry, Sorption, Petroleum product
References
- Confocal imaging analysis of ATP-induced Ca2+ response in individual endothelial cells of the artery in situ.
- Diminished retinoic acid signaling in hepatic stellate cells in cholestatic liver fibrosis.
- Retinoic acid receptors and retinoid X receptor-alpha down-regulate the transforming growth factor-beta 1 promoter by antagonizing AP-1 activity.
- UV Irradiation Activates JNK and Increases αI(I) Collagen Gene Expression in Rat Hepatic Stellate Cells*
- Retinoic Acid Enhances the Production of IL-10 While Reducing the Synthesis of IL-12 and TNF-α from LPS-Stimulated Monocytes/Macrophages
- Retinoic acid repressed the expression of c-fos and c-jun and induced apoptosis in regenerating rat liver after partial hepatectomy.
- Regulation of the murine alpha(2)(I) collagen promoter by retinoic acid and retinoid X receptors.
- Cytokines and Fibrogenesis
- AP-1 as a regulator of cell life and death
- The RXR heterodimers and orphan receptors.
- Vitamin A inhibits pancreatic stellate cell activation: implications for treatment of pancreatic fibrosis
- All-trans and 9-cis retinoic acid alter rat hepatic stellate cell phenotype differentially
- Thioacetamide-induced cirrhosis-like liver lesions in rats--usefulness and reliability of this animal model.
- Pioglitazone prevents early-phase hepatic fibrogenesis caused by carbon tetrachloride.
- Peroxisome Proliferator-activated Receptors and Hepatic Stellate Cell Activation*
- Antidiabetic thiazolidinediones inhibit collagen synthesis and hepatic stellate cell activation in vivo and in vitro.
- Population expansion, clonal growth, and specific differentiation patterns in primary cultures of hepatocytes induced by HGF/SF, EGF and TGF alpha in a chemically defined (HGM) medium
- Differential modulation of rat hepatic stellate phenotype by natural and synthetic retinoids
- The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid.
- Book Review Ethical Problems in Dialysis and Transplantation (Developments in Nephrology. Vol. 33.) Edited by Carl M. Kjellstrand and John B. Dossetor. 235 pp., illustrated. Boston, Kluwer Academic, 1992. $108.50. 0-7923-1625-8
Cited by
- Effect of the regulation of retinoid X receptor‐α gene expression on rat hepatic fibrosis
- Nuclear Receptors as Therapeutic Targets in Liver Disease: Are We There Yet?
- Peroxisome proliferator-activated receptor-γ as a therapeutic target for hepatic fibrosis: from bench to bedside
- Amplified Inhibition of Stellate Cell Activation Pathways by PPAR-γ, RAR and RXR Agonists
- Determination of PPARγ Activity in Adipose Tissue and Spleen
- microRNA-34a and microRNA-34c promote the activation of human hepatic stellate cells by targeting peroxisome proliferator-activated receptor γ.
- Transcriptional regulation of hepatic stellate cells.
- An adenosine derivative compound, IFC305, reverses fibrosis and alters gene expression in a pre-established CCl(4)-induced rat cirrhosis.
- The Interaction between HCV and Nuclear Receptor-mediated Pathways
- Retinoids and nuclear retinoid receptors in white and brown adipose tissues: physiopathologic aspects
- Combination therapy of All-trans Retinoic Acid With Ursodeoxycholic Acid in Patients with Primary Sclerosing Cholangitis – A Human Pilot
- Senescence in hepatic stellate cells as a mechanism of liver fibrosis reversal: a putative synergy between retinoic acid and PPAR-gamma signalings
- Hepatic stellate cells as key target in liver fibrosis
- Novel Anti-fibrotic Therapies
- Nrf2 induces lipocyte phenotype via a SOCS3‐dependent negative feedback loop on JAK2/STAT3 signaling in hepatic stellate cells
- Serelaxin increases the antifibrotic action of rosiglitazone in a model of hepatic fibrosis
- Nrf2 activation is required for curcumin to induce lipocyte phenotype in hepatic stellate cells.
- Emerging therapeutic targets for primary sclerosing cholangitis
- Silencing of tissue factor by antisense deoxyoligonucleotide mitigates thioacetamide-induced liver injury
- Roles of nuclear receptors in hepatic stellate cells
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