Adaptive design methods in clinical trials – a review
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Summary
Several commonly considered adaptive designs in clinical trials are reviewed and some examples concerning the development of Velcade intended for multiple myeloma and non-Hodgkin's lymphoma are given.
- Type
- article
- Published
- 2008-05-02
- Cited by
- 178
- References
- 58
- Access
- Open access
- OpenAlex
- https://openalex.org/W18454853
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:262406198
Keywords
Computer science
References
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- FDA introductory comments: clinical studies design and evaluation issues
- A Hybrid Bayesian Adaptive Design for Dose Response Trials
- Nonparametric Estimation of a Delay Distribution Based on Left‐Censored and Right‐Truncated Data
- Adaptive Two Stage Designs and the Conditional Error Function
- An adaptive method for establishing a dose-response relationship.
- Adaptive design theory and implementation using SAS and R
- Forcing a sequential experiment to be balanced
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- Effects on Motor Development of Kicking and Stepping Exercise in Preterm Infants with Periventricular Brain Injury: A Pilot Study
- Methodological issues for designing and conducting a multicenter, international clinical trial in Acute Stroke: Experience from ARTSS-2 trial.
- Flexible designs for phase II comparative clinical trials involving two response variables
- Systems Pharmacology, Pharmacogenetics, and Clinical Trial Design in Network Medicine
- Bayesian Incentive-Compatible Bandit Exploration
- A framework for applying unfamiliar trial designs in studies of rare diseases.
- Research designs for proof-of-concept chronic pain clinical trials: IMMPACT recommendations
- Mathematical Modeling of Molecular Data in Translational Medicine: Theoretical Considerations
- Novel Statistical Designs for Phase I/II and Phase II Clinical Trials With Dose-Finding Objectives
- Clinical trials in progressive multiple sclerosis: lessons learned and future perspectives
- Patient-centeredness in the design of clinical trials
- Methodological survey of designed uneven randomization trials (DU-RANDOM): a protocol
- The promise of comparative effectiveness research.
- Moderate weight loss in obese and overweight men preserves bone quality.
- An Investigation of the Shortcomings of the CONSORT 2010 Statement for the Reporting of Group Sequential Randomised Controlled Trials: A Methodological Systematic Review
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