OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection

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Summary

Tumor-bearing Rag1-knockout mice reconstituted with OX40-deficient T reg cells and wild-type (WT) effector T cells, or the reciprocal combination, showed that both T reg and effectors must be triggered via Ox40 for the tumor to be rejected.

Type
article
Published
2008-04-14
Cited by
420
References
65
Access
Open access

Keywords

Computer science

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