OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection
Explore this paper's citation graph
Summary
Tumor-bearing Rag1-knockout mice reconstituted with OX40-deficient T reg cells and wild-type (WT) effector T cells, or the reciprocal combination, showed that both T reg and effectors must be triggered via Ox40 for the tumor to be rejected.
- Type
- article
- Published
- 2008-04-14
- Cited by
- 420
- References
- 65
- Access
- Open access
- OpenAlex
- https://openalex.org/W18362171
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:17267045
Keywords
Computer science
References
- Cooperation between CD4 and CD8 T cells for anti‐tumor activity is enhanced by OX40 signals
- Comment on “CCR7 Is Critically Important for Migration of Dendritic Cells in Intestinal Lamina Propria to Mesenteric Lymph Nodes”
- OX40-OX40 Ligand Interaction through T Cell-T Cell Contact Contributes to CD4 T Cell Longevity1
- Costimulation of CD8 T Cell Responses by OX401
- A Signal through OX40 (CD134) Allows Anergic, Autoreactive T Cells to Acquire Effector Cell Functions1
- Signaling through OX40 (CD134) breaks peripheral T-cell tolerance
- Cutting Edge: Anti-CD25 Monoclonal Antibody Injection Results in the Functional Inactivation, Not Depletion, of CD4+CD25+ T Regulatory Cells1
- Natural Regulatory T Cells and De Novo-Induced Regulatory T Cells Contribute Independently to Tumor-Specific Tolerance1
- OX40 Costimulation Synergizes with GM-CSF Whole-Cell Vaccination to Overcome Established CD8+ T Cell Tolerance to an Endogenous Tumor Antigen1
- OX40 Ligand-Transduced Tumor Cell Vaccine Synergizes with GM-CSF and Requires CD40-Apc Signaling to Boost the Host T Cell Antitumor Response1
- Distinct Roles for the OX40-OX40 Ligand Interaction in Regulatory and Nonregulatory T Cells1
- CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs.
- Chemokine receptor CCR7 guides T cell exit from peripheral tissues and entry into afferent lymphatics
- Imaging the function of regulatory T cells in vivo.
- Depletion of CD25+ regulatory cells uncovers immune responses to shared murine tumor rejection antigens
- OX40 (CD134) engagement drives differentiationof CD4+ T cells to effector cells
- Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance
- Activated T cells express the OX40 ligand: requirements for induction and costimulatory function
- Tumor-derived CD4+CD25+ regulatory T cell suppression of dendritic cell function involves TGF-β and IL-10
- The tumor‐draining lymph node as an immune‐privileged site
Cited by
- Immunomodulating antibodies and drugs for the treatment of hematological malignancies
- OX40 ligand expressed in glioblastoma modulates adaptive immunity depending on the microenvironment: a clue for successful immunotherapy
- Biology and clinical observations of regulatory T cells in cancer immunology.
- Cancer immunotherapy targeting T cell costimulatory molecules
- Development and Partial Characterization of Agonistic OX40 Aptamer anti-CBLB siRNA Conjugates
- Cancer immunotherapy: current status and future directions.
- Déviation de l’auto-immunité chez la souris NOD invalidée pour la voie ICOS/ICOSL
- Regulation of virus-specific T cells in the lung during respiratory virus infections
- The Critical Role of TGF-beta1 in the Development of Induced Foxp3+ Regulatory T Cells.
- Exploitation of costimulatory SA-4-1BBL in the development of therapeutic cancer vaccines
- NEGATIVE REGULATION OF REGULATORY T CELLS BY MYELOID-DERIVED SUPPRESSOR CELLS IN CANCER
- Functional implications of TNF-receptor pathways on regulatory T cells
- Cancer immunotherapy in clinical practice—the past, present, and future
- OX40, OX40L and Autoimmunity: a Comprehensive Review
- NEGATIVE MODULATION OF REGULATORY T CELLS AND PROMOTION OF THE TUMORICIDAL ACTIVITY OF DENDRITIC CELLS IN CANCER: A DOUBLE-EDGED STRATEGY
- Immunosuppressive Mechanisms of Malignant Gliomas: Parallels at Non-CNS Sites
- CD4+CD25+ Regulatory T Cells Inhibit Natural Killer Cell Hepatocytotoxicity of Hepatitis B Virus Transgenic Mice via Membrane-Bound TGF-β and OX40
- Trial Watch: Immunomodulatory monoclonal antibodies for oncological indications
- Dysregulation of CD4+CD25hi+ T cells in the synovial fluid of patients with antibiotic-refractory Lyme arthritis
- Evolving synergistic combinations of targeted immunotherapies to combat cancer
Related papers
No related papers recorded.