Chimeric Polyomavirus-Derived Virus-Like Particles: The Immunogenicity of an Inserted Peptide Applied without Adjuvant to Mice Depends on Its Insertion Site and Its Flanking Linker Sequence
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Summary
The results indicate that hamster polyomavirus-derived VLPs represent a highly immunogenic carrier for foreign insertions that might be useful for clinical and therapeutic applications.
- Type
- article
- Published
- 2007-09-01
- Cited by
- 15
- References
- 27
- Access
- Open access
- OpenAlex
- https://openalex.org/W2028565490
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:40274092
Keywords
Immunogenicity, Epitope, Virology, Molecular biology, Capsid
References
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- Seroepidemiology of Human Polyomaviruses
- Generation of virus-like particles consisting of the major capsid protein VP1 of goose hemorrhagic polyomavirus and their application in serological tests.
- Polyoma Virus Pseudocapsids as Efficient Carriers of Heterologous DNA into Mammalian Cells
- Yeast Cells Allow High-Level Expression and Formation of Polyomavirus-Like Particles
- Segments of Puumala Hantavirus Nucleocapsid Protein Inserted into Chimeric Polyomavirus-Derived Virus-Like Particles Induce a Strong Immune Response in Mice
- Recombinant human immunodeficiency Pr55gag virus-like particles presenting chimeric envelope glycoproteins induce cytotoxic T-cells and neutralizing antibodies.
- Size and position of truncations in the carboxy-terminal region of major capsid protein VP1 of hamster polyomavirus expressed in yeast determine its assembly capacity
- Generation of monoclonal antibodies of desired specificity using chimeric polyomavirus-derived virus-like particles.
- Immunological properties of hepatitis B core antigen fusion proteins.
- Virus-like particles derived from major capsid protein VP1 of different polyomaviruses differ in their ability to induce maturation in human dendritic cells.
- Self-assembly of purified polyomavirus capsid protein VP1.
- Carcinoembryonic Antigen in the Staging and Follow-up of Patients with Colorectal Cancer
- Formation of immunogenic virus-like particles by inserting epitopes into surface-exposed regions of hamster polyomavirus major capsid protein.
- Hamster polyomavirus-derived virus-like particles are able to transfer in vitro encapsidated plasmid DNA to mammalian cells
- Purification of recombinant budgerigar fledgling disease virus VP1 capsid protein and its ability for in vitro capsid assembly
- Differential uptake and cross-presentation of human papillomavirus virus-like particles by dendritic cells and Langerhans cells.
Cited by
- Engineered Biological Entities for Drug Delivery and Gene Therapy
- Evaluation of chimeric virus-like particles, capsomeres and bacterial minicells as vaccine delivery platforms
- Vaccination against Her2/neu - expressing cancer using chimeric virus-like particles
- Cellular and Humoral Immunogenicity of Hamster Polyomavirus-Derived Virus-Like Particles Harboring a Mucin 1 Cytotoxic T-Cell Epitope
- Immunogenicity of protein aggregates--concerns and realities.
- The Use of Chimeric Virus-like Particles Harbouring a Segment of Hantavirus Gc Glycoprotein to Generate a Broadly-Reactive Hantavirus-Specific Monoclonal Antibody
- Evaluation of Trichodysplasia Spinulosa-Associated Polyomavirus Capsid Protein as a New Carrier for Construction of Chimeric Virus-Like Particles Harboring Foreign Epitopes
- Development and characterization of artificial viruses for gene therapy
- SAGE: A Fast Computational Tool for Linear Epitope Grafting onto a Foreign Protein Scaffold
- Vaccination with Prion Peptide-Displaying Polyomavirus-Like Particles Prolongs Incubation Time in Scrapie-Infected Mice
- Hamster Polyomavirus Research: Past, Present, and Future
- Yeast-Based Virus-like Particles as an Emerging Platform for Vaccine Development and Delivery
- Immunogenicity of novel vB_EcoS_NBD2 bacteriophage-originated nanotubes as a carrier for peptide-based vaccines
- Investigating the stability of chimeric murine polyomavirus VP1 Capsomeres via molecular dynamics simulations and experimental analysis.
- Développement de nouveaux adjuvants dérivés de pseudoparticules du virus de la mosaïque de la papaye
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