Crystal structures and catalytic mechanism of cytochrome P450 StaP that produces the indolocarbazole skeleton
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Summary
This crystallographic study shows the first crystal structures of enzymes involved in formation of the indolocarbazole core and provides valuable insights into the process of staurosporine biosynthesis, combinatorial biosynthesis of indolOCarbazoles, and the diversity of cytochrome P450 chemistry.
- Type
- article
- Published
- 2007-07-10
- Cited by
- 107
- References
- 45
- Access
- Open access
- OpenAlex
- https://openalex.org/W2082632980
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:29586271
Keywords
Chemistry, Stereochemistry, Oxidative decarboxylation, Staurosporine, Crystal structure
References
- Uncoupling of the cytochrome P-450cam monooxygenase reaction by a single mutation, threonine-252 to alanine or valine: possible role of the hydroxy amino acid in oxygen activation.
- Biosynthesis of Indocarbazostatin B, Incorporation of D-[U-13C] Glucose and L-[2-13C] Tryptophan
- The PyMOL Molecular Graphics System
- A role for Asp-251 in cytochrome P-450cam oxygen activation.
- The 2.6-A crystal structure of Pseudomonas putida cytochrome P-450.
- The nature of .pi.-.pi. interactions
- Direct formation of chromopyrrolic acid from indole-3-pyruvic acid by StaD, a novel hemoprotein in indolocarbazole biosynthesis
- Pulse radiolytic measurement of redox potentials: the tyrosine and tryptophan radicals.
- Crystal Structure of a Thermophilic Cytochrome P450 from the Archaeon Sulfolobus solfataricus *
- Enzymatic assembly of the bis-indole core of rebeccamycin.
- The many roles of cytochrome b5.
- Mechanism of tryptophan oxidation by some inorganic radical-anions: a pulse radiolysis study
- Compound I radical in site-directed mutants of cytochrome c peroxidase as probed by electron paramagnetic resonance and electron-nuclear double resonance.
- A program to produce both detailed and schematic plots of protein structures
- Electrostatics of nanosystems: Application to microtubules and the ribosome
- A kinetic study of the endogenous reduction of the oxidized sites in the primary cytochrome c peroxidase-hydrogen peroxide compound.
- Chlorination by a long-lived intermediate in the mechanism of flavin-dependent halogenases.
- Comparison of the dynamics of substrate access channels in three cytochrome P450s reveals different opening mechanisms and a novel functional role for a buried arginine
- Cytochrome P450: Structure, mechanism, and biochemistry
- Probing the open state of cytochrome P450cam with ruthenium-linker substrates
Cited by
- Synthetic Biology Approaches to New Bisindoles.
- Chapter 19. In vitro studies of phenol coupling enzymes involved in vancomycin biosynthesis.
- QM/MM study of the C—C coupling reaction mechanism of CYP121, an essential Cytochrome p450 of Mycobacterium tuberculosis
- Total (Bio)Synthesis: Strategies of Nature and of Chemists
- Design and synthesis of peptide inhibitor conjugates as probes of the Cytochrome P450s from glycopeptide antibiotic biosynthesis
- Structural insights from a P450 Carrier Protein complex reveal how specificity is achieved in the P450BioI ACP complex
- Structural fine-tuning of a multifunctional cytochrome P450 monooxygenase.
- Crystal Structure of VioE, a Key Player in the Construction of the Molecular Skeleton of Violacein*
- Selective tryptophan determination using tryptophan oxidases involved in bis-indole antibiotic biosynthesis.
- Diversity of P450 Enzymes in the Biosynthesis of Natural Products
- Cooperative properties of cytochromes P450
- Rebeccamycin and Staurosporine Biosynthesis: Insight into the Mechanisms of the Flavin‐Dependent Monooxygenases RebC and StaC
- A pair of unprecedented spiro-trisindole enantiomers fused through a five-member ring from Laurencia similis
- Cytochrome P450 monooxygenases: an update on perspectives for synthetic application.
- Crystal structure of H2O2-dependent cytochrome P450SPalpha with its bound fatty acid substrate: insight into the regioselective hydroxylation of fatty acids at the alpha position.
- Identification and structural basis of the reaction catalyzed by CYP121, an essential cytochrome P450 in Mycobacterium tuberculosis
- Regio- and Stereospecificity of Filipin Hydroxylation Sites Revealed by Crystal Structures of Cytochrome P450 105P1 and 105D6 from Streptomyces avermitilis*
- Indolocarbazole antitumour compounds by combinatorial biosynthesis.
- Spiroindimicins A-D: new bisindole alkaloids from a deep-sea-derived actinomycete.
- Cloning, Characterization and Heterologous Expression of the Indolocarbazole Biosynthetic Gene Cluster from Marine-Derived Streptomyces sanyensis FMA
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