Tissue-specific transcription factor HNF4α inhibits cell proliferation and induces apoptosis in the pancreatic INS-1 β-cell line
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Summary
It is proposed that the anti-proliferative and apoptotic properties of HNF4α may be an essential feature impaired in MODY1 and possibly also in type 2 diabetes.
- Type
- article
- Published
- 2007-01-01
- Cited by
- 34
- References
- 59
- OpenAlex
- https://openalex.org/W17214554
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25215319
Keywords
Political science
References
- An alternative splice variant of the tissue specific transcription factor HNF4alpha predominates in undifferentiated murine cell types.
- Apoptosis-inducing factor: vital and lethal.
- KAI1 gene expression in colonic carcinoma and its clinical significances
- Naturally occurring mutations in the human 5-lipoxygenase gene promoter that modify transcription factor binding and reporter gene transcription.
- Hepatocyte nuclear factor 4alpha regulates the expression of pancreatic beta -cell genes implicated in glucose metabolism and nutrient-induced insulin secretion.
- RIP-Cre Revisited, Evidence for Impairments of Pancreatic β-Cell Function*
- Digging deep into the pockets of orphan nuclear receptors: insights from structural studies.
- Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes.
- MODY1 mutation Q268X in hepatocyte nuclear factor 4alpha allows for dimerization in solution but causes abnormal subcellular localization.
- Transcriptional networks controlling pancreatic development and beta cell function
- HNF-4alpha: from MODY to late-onset type 2 diabetes.
- Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young.
- Hepatic function in a family with a nonsense mutation (R154X) in the hepatocyte nuclear factor-4alpha/MODY1 gene.
- Activation of p21CIP1/WAF1 gene expression and inhibition of cell proliferation by overexpression of hepatocyte nuclear factor-4alpha.
- Developmentally Regulated N-terminal Variants of the Nuclear Receptor Hepatocyte Nuclear Factor 4α Mediate Multiple Interactions through Coactivator and Corepressor-Histone Deacetylase Complexes*
- The activation function-1 of hepatocyte nuclear factor-4 is an acidic activator that mediates interactions through bulky hydrophobic residues.
- Maturity-onset diabetes of the young Type 1 (MODY1)-associated mutations R154X and E276Q in hepatocyte nuclear factor 4alpha (HNF4alpha) gene impair recruitment of p300, a key transcriptional co-activator.
- Critical Structural Elements and Multitarget Protein Interactions of the Transcriptional Activator AF-1 of Hepatocyte Nuclear Factor 4*
- Expression of HNF4α isoforms in mouse liver development is regulated by sequential promoter usage and constitutive 3′ end splicing
- Characterization of a dominant negative mutant form of the HNF-4 orphan receptor.
Cited by
- Altering TET dioxygenase levels within physiological range affects DNA methylation dynamics of HEK293 cells
- MicroRNAs Regulate Human Hepatocyte Nuclear Factor 4α, Modulating the Expression of Metabolic Enzymes and Cell Cycle*
- PED interacts with Rac1 and regulates cell migration/invasion processes in human non‐small cell lung cancer cells
- A Unique Four-Hub Protein Cluster Associates to Glioblastoma Progression
- Hepatocyte Nuclear Factor 4 alpha Deletion Promotes Diethylnitrosamine-induced Hepatocellular Carcinoma in Mice
- HNF4α orchestrates a set of 14 genes to down-regulate cell proliferation in kidney cells
- A Systematic Analysis of the 3′UTR of HNF4A mRNA Reveals an Interplay of Regulatory Elements Including miRNA Target Sites
- Improved conditional expression systems resulting in physiological level of HNF4α expression confirm HNF4α induced apoptosis in the pancreatic β-cell line INS-1
- Exposure to omega-3 fatty acids at early age accelerate bone growth and improve bone quality.
- Hepatocyte-specific deletion of hepatocyte nuclear factor-4α in adult mice results in increased hepatocyte proliferation.
- Impact of transcriptional and posttranscriptional regulation of HNF4A and its target genes on diabetes and cancer
- Developmental programming of neonatal pancreatic β-cells by a maternal low-protein diet in rats involves a switch from proliferation to differentiation.
- Nuclear receptor hepatocyte nuclear factor 4alpha1 competes with oncoprotein c-Myc for control of the p21/WAF1 promoter.
- Tissue-specific transcription factors in progression of epithelial tumors
- Differential Effects of Hepatocyte Nuclear Factor 4α Isoforms on Tumor Growth and T-Cell Factor 4/AP-1 Interactions in Human Colorectal Cancer Cells
- The Role of the P1 and P2 Promoter-Driven HNF4a Isoforms in Cellular Proliferation and Differentiation in Human Colon Cancer and Mouse Embryonic Stem Cells
- Impairment of hepatic nuclear factor-4α binding to the Stim1 promoter contributes to high glucose-induced upregulation of STIM1 expression in glomerular mesangial cells.
- Identification of novel mechanisms of glucolipotoxicity in type 2 diabetes
- [Analysis of 3',5' reversed-sequence oligonucleotide isomers by reversed-phase ion-pair chromatography].
- High Glucose-induced Upregulation of STIM1 Expression in Glomerular Mesangial Cells 2
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