Pax2/5/8 proteins promote cell survival in C. elegans
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Summary
Using genetic and molecular experiments, this work shows that the Pax proteins act as transcriptional regulators of ced-9, the C. elegans bcl-2 gene, and underscores the importance of transcriptional regulation of core apoptotic pathway genes in influencing cell survival.
- Type
- article
- Published
- 2006-11-01
- Cited by
- 57
- References
- 54
- OpenAlex
- https://openalex.org/W1996724986
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:2841551
Keywords
Biology, Programmed cell death, Somatic cell, Cell biology, Transcription factor
References
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- Caenorhabditis elegans p53: Role in Apoptosis, Meiosis, and Stress Resistance
- Regulation of Neurotransmitter Vesicles by the Homeodomain Protein UNC-4 and Its Transcriptional Corepressor UNC-37/Groucho inCaenorhabditis elegans Cholinergic Motor Neurons
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- Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells
- Evolution of regulatory elements producing a conserved gene expression pattern in Caenorhabditis
- Hypomethylation-linked activation of PAX2 mediates tamoxifen-stimulated endometrial carcinogenesis
- The embryonic cell lineage of the nematode Halicephalobus gingivalis (Nematoda: Cephalobina: Panagrolaimoidea)
- Paired-Box genes are frequently expressed in cancer and often required for cancer cell survival
- Genome-wide RNAi identifies p53-dependent and -independent regulators of germ cell apoptosis in C. elegans
- Caenorhabditis elegans operons: form and function
Cited by
- C. elegans orthologs of components of the RB tumor suppressor complex have distinct pro-apoptotic functions
- Polymorphism in lncRNA AC016683.6 and its interaction with smoking exposure on the susceptibility of lung cancer
- Comparison of ZnO nanoparticles and ZnCl2 induced germ cell apoptosis in Caenorhabditis elegans
- Germ cell apoptosis and DNA damage responses.
- Noncanonical cell death in the nematode Caenorhabditis elegans
- The zebrafish model to identify new genes involved in thyroid development
- The role of Pax7 in the formation of tbe superior colliculus and the vertebrate visual system
- PAX6 in mammalian degenerative retina
- Ribosome Synthesis and MAPK Activity Modulate Ionizing Radiation-Induced Germ Cell Apoptosis in Caenorhabditis elegans
- The transcription factor PAX4 acts as a survival gene in INS-1E insulinoma cells
- The PAX258 gene subfamily: A comparative perspective
- Cell lineage and cell death: Caenorhabditis elegans and cancer research
- Minireview: Intrinsic and extrinsic factors in thyroid gland development: an update.
- Zebrafish bcl2l is a survival factor in thyroid development.
- PAX5 is expressed in small cell lung cancer and positively regulates c-Met transcription
- Gene expression profiling at early organogenesis reveals both common and diverse mechanisms in foregut patterning
- Development of cellular immune responses against PAX5, a novel target for cancer immunotherapy.
- Pax genes during neural development and their potential role in neuroregeneration.
- The paired box transcription factor Pax8 is essential for function and survival of adult thyroid cells.
- Reactive Oxygen Species and Aging in Caenorhabditis elegans: Causal or Casual Relationship?
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