Discovery of cancer vaccination protocols with a genetic algorithm driving an agent based simulator

Jerónimo Merelo y Sayró, Arte Mayor de la Seda · BMC Bioinformatics · 2006

Summary

A simulator (SimTriplex) is developed which describes the immune response activated by Triplex vaccine and suggests that maximal protection could still be obtained with a number of vaccinations ~40% less than with the Chronic protocol.

Type: article
Published: 2006-07-20
Cited by: 80
References: 19
Access: Open access
DOI: https://doi.org/10.1186/1471-2105-7-352
PubMed: https://pubmed.ncbi.nlm.nih.gov/16857043/
PMC: https://www.ncbi.nlm.nih.gov/pmc/articles/1557867/
OpenAlex: https://openalex.org/W16857043
Semantic Scholar: https://api.semanticscholar.org/CorpusID:8156529

Keywords

Humanities, Art

References

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Cited by

A systems biology approach to multi-scale modelling and analysis of planar cell polarity in drosophila melanogaster wingQian Gao — 2013
Preclinical development of cancer vaccinesA. Palladini — 2009
Computational Systems Biology in Cancer: Modeling Methods and ApplicationsWayne Materi, David S. Wishart — 2007
The triplex vaccine effects in mammary carcinoma: A nonlinear model in tune with SimTriplex ☆Carlo Bianca, Marzio Pennisi — 2012
Bioinformatics for study of autoimmunityNikolai Petrovsky, Vladimir Brusić — 2006
MODELING TUMOR IMMUNOLOGYPier‐Luigi Lollini, Santo Motta, Francesco Pappalardo — 2006
Immunoinformatics and Modeling Perspective of T Cell Epitope-Based Cancer Immunotherapy: A Holistic PictureSeema Mishra, Subrata Sinha — 2009
The Separatrix Algorithm for Synthesis and Analysis of Stochastic Simulations with Applications in Disease ModelingDaniel J. Klein, Michael Baym, Philip A. Eckhoff — 2014
Vaccine protocols optimization: in silico experiences.Francesco Pappalardo, Marzio Pennisi, Filippo Castiglione — 2010
Modeling the adaptive immune system: predictions and simulationsClaus Lundegaard, Ole Lund, Can Keşmir — 2007
Development of Immune-Specific Interaction Potentials and Their Application in the Multi-Agent-System VaccImmAnna Lena Woelke, Joachim von Eichborn, Manuela S. Murgueitio — 2011
Interactions Between the Immune System and Cancer: A Brief Review of Non-spatial Mathematical ModelsRaluca Eftimie, Jonathan L. Bramson, David J. D. Earn — 2011
Harnessing bioinformatics to discover new vaccines.Matthew N. Davies, Darren R. Flower — 2007
Computational Simulations of the Immune System for Personalized Medicine: State of the Art and ChallengesFrancesco Pappalardo, Ping Zhang, Mark Halling‐Brown — 2008
Emerging Vaccine InformaticsYongqun He, Rino Rappuoli, Anne S. De Groot — 2011
Using difference equations to find optimal tax structures on the SugarScapeMatthew Oremland, Reinhard Laubenbacher — 2014
An algorithm designed for improving diagnostic efficiency by setting multi-cutoff values of multiple tumor markersQiang Su, Jinghua Shi, Ping Gu — 2012
The MWF method: A convergence theorem for homogeneous one-dimensional caseCarlo Bianca, Santo Motta — 2009
Optimal Harvesting for a Predator-Prey Agent-Based Model using Difference EquationsMatthew Oremland, Reinhard Laubenbacher — 2015
Multi-agent model of hepatitis C virus infectionSzymon Wąsik, Paulina Jackowiak, Marek Figlerowicz — 2014

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