In vitro toxicology evaluation of pharmaceuticals using Raman micro‐spectroscopy
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Summary
Raman micro‐spectroscopy combined with multivariate analysis was employed to monitor real‐time biochemical changes induced in living cells in vitro following exposure to a pharmaceutical, indicating a significant level of DNA fragmentation and apoptosis in etoposide treated cells.
- Type
- dissertation
- Published
- 2006-09-01
- Cited by
- 95
- References
- 28
- Access
- Open access
- OpenAlex
- https://openalex.org/W16598770
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:26120463
Keywords
Humanities, Political science, Philosophy
References
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- Biochemical composition of human peripheral arteries examined with near-infrared Raman spectroscopy.
- In situ monitoring of cell death using Raman microspectroscopy.
- Standard Normal Variate Transformation and De-Trending of Near-Infrared Diffuse Reflectance Spectra
- In vivo confocal Raman microspectroscopy of the skin: noninvasive determination of molecular concentration profiles.
- Serum withdrawal and etoposide induce apoptosis in human lung carcinoma cell line A549 via distinct pathways
- The structure and function of drug pumps: an update.
- Identification of organelles and vesicles in single cells by Raman microspectroscopic mapping
- Etoposide: four decades of development of a topoisomerase II inhibitor.
- The effect of preprocessing methods in reducing interfering variability from near-infrared measurements of creams.
- A New Type of Secondary Radiation
- Studying single living cells and chromosomes by confocal Raman microspectroscopy
- Bioanalytical applications of Raman spectroscopy
- Nonresonant confocal Raman imaging of DNA and protein distribution in apoptotic cells.
- Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
Cited by
- Label-Free Raman Spectroscopic Imaging Monitors the Integral Physiologically Relevant Drug Responses in Cancer Cells.
- Raman spectroscopy for physiological investigations of tissues and cells.
- Interactions of Carbon Nanotubes with Human Lung Epithelial Cells In Vitro, Assessed by Raman Spectroscopy
- Evaluation of the potential of Raman microspectroscopy for prediction of chemotherapeutic response to cisplatin in lung adenocarcinoma.
- Comparison of subcellular responses for the evaluation and prediction of the chemotherapeutic response to cisplatin in lung adenocarcinoma using Raman spectroscopy.
- Investigation of biochemical property changes in activation-induced CD8+ T cell apoptosis using Raman spectroscopy
- In Vitro, Non-Invasive Imaging and Detection of Single Living Mammalian Cells Interacting with Bio-Nano-Interfaces
- Bioactive glass-induced osteoblast differentiation: a noninvasive spectroscopic study.
- Sensing Biophysical Alterations of Human Lung Epithelial Cells (A549) in the Context of Toxicity Effects of Diesel Exhaust Particles
- Toxicity effects of short term diesel exhaust particles exposure to human small airway epithelial cells (SAECs) and human lung carcinoma epithelial cells (A549)
- Noninvasive detection and imaging of molecular markers in live cardiomyocytes derived from human embryonic stem cells.
- Detecting viability transitions of umbilical cord mesenchymal stem cells by Raman micro-spectroscopy
- Raman microspectroscopy for non-invasive biochemical analysis of single cells.
- A simple and rapid detection of tissue adhesive-induced biochemical changes in cells and DNA using Raman spectroscopy.
- Progress in Raman spectroscopy in the fields of tissue engineering, diagnostics and toxicological testing
- A DFT Calculation: Toxicity of Water Soluble Arsenicals
- Raman spectroscopy and support vector machines for quick toxicological evaluation of titania nanoparticles
- In vivo and in situ monitoring of the nitric oxide stimulus response of single cancer cells by Raman spectroscopy
- Assessment of cell line models of primary human cells by Raman spectral phenotyping.
- Evaluation of antibiotic effects on Pseudomonas aeruginosa biofilm using Raman spectroscopy and multivariate analysis.
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