Glutathione regulates susceptibility to oxidant-induced mitochondrial DNA damage in human lymphocytes.
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Summary
The findings implicate the glutathione system in maintaining mtDNA integrity and resistance to apoptosis in lymphocytes and suggest that assessment of mtDNA damage in blood lymphocytes may be a useful marker of oxidative stress in humans.
- Type
- article
- Published
- 2006-04-01
- Cited by
- 31
- References
- 36
- OpenAlex
- https://openalex.org/W16545690
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:42907790
Keywords
Diamagnetism, Polymethyl methacrylate, Materials science, Magnetic field, Composite material
References
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Cited by
- High glucose increases susceptibility to oxidative-stress-induced apoptosis and DNA damage in K-562 cells.
- Experimental treatments for mitochondrial dysfunction in sepsis: A narrative review
- Exploiting the Bioenergetics of Disease-Causing Lymphocytes for Selective Immunomodulation.
- Later-life Effects of Mitochondrial DNA Damage During Development in the Whole Organism Model Caenorhabditis elegans
- GLUTATHIONE SYNTHESIS AGAINST OXIDANT INJURY BY PEROXIDES IN TWO ALVEOLAR EPITHELIAL CELL LINES
- REACTIVE OXYGEN SPECIES, CELLULAR REDOX SYSTEMS AND APOPTOSIS
- Dimethyl fumarate – only an anti‐psoriatic medication?
- Hypoxia influences CD40-CD40L mediated inflammation in endothelial and monocytic cells.
- Contribution of glutathione status to oxidant-induced mitochondrial DNA damage in colonic epithelial cells
- Dimethylfumarat “nur” ein Anti‐Psoriatikum?
- Differential effect of creatine on oxidatively-injured mitochondrial and nuclear DNA.
- Irreversible cytoskeletal disarrangement is independent of caspase activation during in vitro azaspiracid toxicity in human neuroblastoma cells.
- Detection of metabolites of fumaric acid esters in human urine: implications for their mode of action.
- Exposure to Mitochondrial Genotoxins and Dopaminergic Neurodegeneration in Caenorhabditis elegans
- QPCR: a tool for analysis of mitochondrial and nuclear DNA damage in ecotoxicology
- Dimethyl fumarate in relapsing–remitting multiple sclerosis: rationale, mechanisms of action, pharmacokinetics, efficacy and safety
- Apoptosis and glutathione: beyond an antioxidant
- Mitochondrial and cytosolic thiol redox state are not detectably altered in isolated human NADH:ubiquinone oxidoreductase deficiency.
- Protective effect of acetyl-l-carnitine and α-lipoic acid against the acute toxicity of diepoxybutane to human lymphocytes.
- Mitochondria as a Target of Environmental Toxicants
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