Paclitaxel-resistant cells have a mutation in the paclitaxel-binding region of β-tubulin (Asp26Glu) and less stable microtubules
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Summary
It is suggested that a mutation in tubulin might affect microtubule stability as well as drug binding and contribute to the observed resistance profile.
- Type
- article
- Published
- 2006-02-01
- Cited by
- 148
- References
- 48
- Access
- Open access
- OpenAlex
- https://openalex.org/W16505100
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:538635
Keywords
Humanities, Philosophy
References
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- Asymmetric Binding to NS5A by Daclatasvir (BMS-790052) and Analogs Suggests Two Novel Modes of HCV Inhibition
- Etablissement d'un nouveau modèle pérclinique de cancer de la prostate et identification de biomarqueurs de résistance au docetaxel
- Resistance to microtubule-stabilising agents following point mutation of human βI-tubulin
- βI-tubulin mutations in the laulimalide/peloruside binding site mediate drug sensitivity by altering drug-tubulin interactions and microtubule stability.
- Les poisons du fuseau
- The tubulin binding mode of microtubule stabilizing agents studied by electron crystallography.
- Nanoparticle-mediated drug delivery for treating melanoma
- Carboplatin and taxol resistance develops more rapidly in functional BRCA1 compared to dysfunctional BRCA1 ovarian cancer cells.
- miR-337-3p and Its Targets STAT3 and RAP1A Modulate Taxane Sensitivity in Non-Small Cell Lung Cancers
- Expression of recombinant alpha and beta tubulins from the yew Taxus cuspidata and analysis of the microtubule assembly in the presence of taxol
- Structural and biological characterization of the tubulin interaction with dinitroanilines
- Resistance to Chemotherapy in Cancer: A Complex and Integrated Cellular Response
- New tubulin targeting agents currently in clinical development
- Amino acid substitutions at proline 220 of β-tubulin confer resistance to paclitaxel and colcemid
- Combining Paclitaxel with ABT-263 Has a Synergistic Effect on Paclitaxel Resistant Prostate Cancer Cells
- New insights into mechanisms of resistance to microtubule inhibitors
- A phase II study of milataxel: a novel taxane analogue in previously treated patients with advanced colorectal cancer
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