The thrombopoietin receptor, c-Mpl, is a selective surface marker for human hematopoietic stem cells
Explore this paper's citation graph
Summary
The hypothesis that the TPO receptor, c-mpl, participates in the regulation of primitive human HSC from mid-fetal through adult life is supported and it is suggested that c- mpl merits consideration as a selective surface marker for the identification and isolation of human H SC in both basic research and clinical settings.
- Type
- article
- Published
- 2006-02-16
- Cited by
- 55
- References
- 90
- Access
- Open access
- OpenAlex
- https://openalex.org/W16480521
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:8245652
Keywords
Humanities, Philosophy, Physics
References
- Outcome of cord-blood transplantation from related and unrelated donors. Eurocord Transplant Group and the European Blood and Marrow Transplantation Group.
- Importance of CD34+ cell subsets in autologous PBSC transplantation: the mulhouse experience using CD34+CD38- cells as predictive tool for hematopoietic engraftment.
- Sequential generations of hematopoietic colonies derived from single nonlineage-committed CD34+CD38- progenitor cells.
- AC133, a novel marker for human hematopoietic stem and progenitor cells.
- CD34: structure, biology, and clinical utility.
- Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl.
- Human T cells in the SCID-hu mouse are phenotypically normal and functionally competent.
- Antigenic analysis of hematopoiesis. III. A hematopoietic progenitor cell surface antigen defined by a monoclonal antibody raised against KG-1a cells.
- GM-CSF-mobilized peripheral blood CD34+ cells differ from steady-state bone marrow CD34+ cells in adhesion molecule expression
- Role of the CD34+38− cells in posttransplant hematopoietic recovery
- Mobilization of CD34+ haematopoietic stem cells is associated with a functional inactivation of the integrin very late antigen 4
- Modulation of VLA-4 and L-selectin expression on normal CD34+ cells during mobilization with G-CSF
- Primordial role of CD34+38− cells in early and late trilineage haemopoietic engraftment after autologous blood cell transplantation
- Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: identification of a member of the hematopoietic growth factor receptor superfamily.
- CD133+ Cell Selection Is an Alternative to CD34+ Cell Selection for Ex Vivo Expansion of Hematopoietic Stem Cells
- c-mpl mutations are the cause of congenital amegakaryocytic thrombocytopenia.
- Thrombopoietin, flt3‐ligand and c‐kit‐ligand modulate HOX gene expression in expanding cord blood CD133+ cells
- A journey through flow cytometric immunofluorescence analyses—Finding accurate and robust algorithms that estimate positive fraction distributions
- The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function.
- Isolation of primitive human hematopoietic progenitors on the basis of aldehyde dehydrogenase activity.
Cited by
- Cooperating Events in Core Binding Factor Leukemia Development: A Dissertation
- Hematopoietic stem cells.
- The role of Src homology 2 domain containing 5' inositol phosphatase 1 (SHIP) in hematopoietic cells
- Results of a randomized, double-blind study of romiplostim versus placebo in patients with low/intermediate-1–risk myelodysplastic syndrome and thrombocytopenia
- The Role of Kit and Thrombopoietin in Regulation of Hematopoietic Stem Cells
- Thrombopoietin is a growth factor for rat hepatic progenitors
- Effect of hematopoietic growth factors on severity of experimental autoimmune encephalomyelitis
- Immobilisation of a thrombopoietin peptidic mimic by self-assembled monolayers for culture of CD34+ cells.
- Hypoxia-Induced Down-Regulation of microRNA-34a Promotes EMT by Targeting the Notch Signaling Pathway in Tubular Epithelial Cells
- Vaccination with xenogeneic tumor endothelial proteins isolated in situ inhibits tumor angiogenesis and spontaneous metastasis
- Expansion of multipotent and lymphoid-committed human progenitors through intracellular dimerization of Mpl.
- Itga2b Regulation at the Onset of Definitive Hematopoiesis and Commitment to Differentiation
- Incomplete restoration of Mpl expression in the mpl-/- mouse produces partial correction of the stem cell-repopulating defect and paradoxical thrombocytosis.
- Changes in the Peripheral Blood Transcriptome Associated with Occupational Benzene Exposure Identified by Cross-Comparison on Two Microarray Platforms
- Differential requirements for Wnt and Notch signaling in hematopoietic versus thymic niches
- A patient-derived olfactory stem cell disease model for ataxia-telangiectasia.
- Overview of thrombopoietic agents in the treatment of thrombocytopenia.
- Sox17 as a candidate regulator of myeloid restricted differentiation potential
- Monoclonal antibody 1.6.1 against human MPL receptor allows HSC enrichment of CB and BM CD34(+)CD38(-) populations.
- H2S protects against fatal myelosuppression by promoting the generation of megakaryocytes/platelets
Related papers
No related papers recorded.