Two types of cytotoxic lymphocyte regulation explain kinetics of immune response to human immunodeficiency virus.
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Summary
It is predicted that individuals with a high virus load can be switched to a low-viremia state that will maintain stability after therapy, but the switch requires fine adjustment of therapy regimen based on the model and individual parameters.
- Type
- article
- Published
- 2006-01-17
- Cited by
- 23
- References
- 39
- Access
- Open access
- OpenAlex
- https://openalex.org/W16407101
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25777468
Keywords
Instrumentation (computer programming), Set (abstract data type), Computer science, Engineering, Programming language
References
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- Rapid turnover of T lymphocytes in SIV-infected rhesus macaques.
- Human Immunodeficiency Virus-Specific CD8+ T-Cell Responses Do Not Predict Viral Growth and Clearance Rates during Structured Intermittent Antiretroviral Therapy
- Peak SIV replication in resting memory CD4+ T cells depletes gut lamina propria CD4+ T cells
- Adjoint equations and analysis of complex systems: application to virus infection modelling
- Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection
- Modelling the dynamics of LCMV infection in mice: conventional and exhaustive CTL responses.
- HIV-1 Dynamics in Vivo: Virion Clearance Rate, Infected Cell Life-Span, and Viral Generation Time
- Mathematical models of immune effector responses to viral infections: Virus control versus the development of pathology
- Increased rates of CD4(+) and CD8(+) T lymphocyte turnover in simian immunodeficiency virus-infected macaques.
- The Critical Need for CD4 Help in Maintaining Effective Cytotoxic T Lymphocyte Responses
- Rapid evolution of the neutralizing antibody response to HIV type 1 infection
- Dynamics of cytotoxic T–lymphocyte exhaustion
- Critical Role for Alpha/Beta and Gamma Interferons in Persistence of Lymphocytic Choriomeningitis Virus by Clonal Exhaustion of Cytotoxic T Cells
Cited by
- Constraints on the Dominant Mechanism for HIV Viral Dynamics in Patients on Raltegravir
- The Impact of CD8⁺ T Cell Killing on the Within-Host Dynamics and Evolution of Virus Infections
- Stability analysis of delay differential equation models of HIV-1 therapy for fighting a virus with another virus
- Design Requirements for Interfering Particles To Maintain Coadaptive Stability with HIV-1
- Estimate of effective recombination rate and average selection coefficient for HIV in chronic infection
- Model with Two Types of CTL regulation and Experiments on CTL Dynamics
- The Effect of Interference on the CD8+ T Cell Escape Rates in HIV
- Increasing sequence correlation limits the efficiency of recombination in a multisite evolution model.
- An Efficient Therapy Strategy under a Novel HIV Model
- Low-level HIV-1 replication and the dynamics of the resting CD4+ T cell reservoir for HIV-1 in the setting of HAART
- Physical theory of the competition that allows HIV to escape from the immune system.
- Dynamical models of biomarkers and clinical progression for personalized medicine: the HIV context.
- The Route of HIV Escape from Immune Response Targeting Multiple Sites Is Determined by the Cost-Benefit Tradeoff of Escape Mutations
- Decay dynamics of HIV-1 depend on the inhibited stages of the viral life cycle
- Superinfection with a heterologous HIV strain per se does not lead to faster progression.
- Interpreting the effect of vaccination on steady state infection in animals challenged with Simian Immunodeficiency Virus
- Understanding the Failure of CD8+ T-Cell Vaccination against Simian/Human Immunodeficiency Virus
- MODELO MATEMÁTICO DA RESPOSTA IMUNE À INFECÇÃO PELO VÍRUS HIV-1
- Kinetics of the viral cycle influence pharmacodynamics of antiretroviral therapy
- Modeling the immune response to HIV infection
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