Right place, right time, right peptide: DO keeps DM focused
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Summary
This review of the literature pertaining to DO assembly, transport, and function, with an emphasis on the function of DO/H‐2O, finds that in B cells, the expression of H‐2 O promotes the presentation of antigens internalized by the B‐cell receptor.
- Type
- article
- Published
- 2005-10-01
- Cited by
- 82
- References
- 123
- OpenAlex
- https://openalex.org/W16181343
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:28314778
Keywords
Routing (electronic design automation), Computer science, Business, Computer network
References
- HLA-DO is a negative modulator of HLA-DM-mediated MHC class II peptide loading.
- Class II transactivator-induced expression of HLA-DO(beta) in HeLa cells.
- DO beta: a new beta chain gene in HLA‐D with a distinct regulation of expression.
- DM enhances peptide binding to class II MHC by release of invariant chain-derived peptide.
- Inhibition of endosomal proteolytic activity by leupeptin blocks surface expression of MHC class II molecules and their conversion to SDS resistance alpha beta heterodimers in endosomes.
- Class II genes of the human major histocompatibility complex. The DO beta gene is a divergent member of the class II beta gene family.
- DMA and DMB are the only genes in the class II region of the human MHC needed for class II-associated antigen processing.
- Isolation and characterization of the cDNA clone and genomic clones of a new HLA class II antigen heavy chain, DO alpha.
- Pillars Article: Complementation Cloning of an MHC Class II Transactivator Mutated in Hereditary MHC Class II Deficiency (or Bare Lymphocyte Syndrome). Cell 1993. 75: 135–146.
- MHC class II-restricted antigen processing and presentation.
- Monoclonal antibody detection of a major self peptide. MHC class II complex.
- MHC class II deletion mutant expresses normal levels of transgene encoded class II molecules that have abnormal conformation and impaired antigen presentation ability.
- CIITA coordinates multiple histone acetylation modifications at the HLA-DRA promoter
- Analysis of H2-O Influence on Antigen Presentation by B Cells
- Ectopic Expression of HLA-DO in Mouse Dendritic Cells Diminishes MHC Class II Antigen Presentation1
- The antigen-processing mutant T2 suggests a role for MHC-linked genes in class II antigen presentation.
- Dendritic cells and the control of immunity
- The human HLA class II alpha chain gene DZ alpha is distinct from genes in the DP, DQ and DR subregions.
- Class II Transactivator Is Required for Maximal Expression of HLA-DOB in B Cells1
- HLA‐DO is a lysosomal resident which requires association with HLA‐DM for efficient intracellular transport.
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- The role of HLA-B27 in inflammatory arthritis
- Processing and presentation of the rheumatoid arthritis candidate autoantigen aggrecan, by antigen-specific B cells
- Immunodeficiency and Autoimmunity in H2-O–Deficient Mice
- Posttranslational Regulation of I-Ed by Affinity for CLIP1
- Type B Presentation from HEL Protein in the Context of Inflammation
- Investigation of the T helper cell response against Epstein-Barr virus
- Autophagy and antigen processing : strategies to enhance T cell recognition of cancer cells
- Elevation of c-MYC Disrupts HLA Class II-mediated Immune Recognition of Human B-cell Tumors
- Expression Patterns of H2-O in Mouse B Cells and Dendritic Cells Correlate with Cell Function1
- Genetic variants in antigen presentation-related genes influence susceptibility to hepatitis C virus and viral clearance: a case control study
- HLA-DO and Its Role in MHC Class II Antigen Presentation
- Inhibition of HLA-DM Mediated MHC Class II Peptide Loading by HLA-DO Promotes Self Tolerance
- Endogenous HLA class II epitopes that are immunogenic in vivo show distinct behavior toward HLA-DM and its natural inhibitor HLA-DO.
- Generation of MHC class II:peptide ligands for CD4 T cell allorecognition of MHC Class II molecules
- Higher Throughput Methods of Identifying T Cell Epitopes for Studying Outcomes of Altered Antigen Processing and Presentation
- The lymph as a pool of self antigens
- Carrying Yourself: Self Antigen Composition of the Lymphatic Fluid
- MHC class II antigen presentation by dendritic cells regulated through endosomal sorting.
- The Peptide Specificity of the Endogenous T Follicular Helper Cell Repertoire Generated after Protein Immunization
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