Probing the mechanism of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III mtFabH: factors influencing catalysis and substrate specificity.
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Summary
The structural studies suggested that His(258), previously implicated in malonyl-ACP decarboxylation, also acts as an anchor point for a network of water molecules that the authors propose promotes deprotonation and transacylation of Cys(122).
- Type
- article
- Published
- 2005-09-16
- Cited by
- 60
- References
- 45
- OpenAlex
- https://openalex.org/W16040614
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:44740732
Keywords
PlanetLab, Dynamism, Scalability, Computer science, Peer-to-peer
References
- Effective electron-density map improvement and structure validation on a Linux multi-CPU web cluster: The TB Structural Genomics Consortium Bias Removal Web Service.
- Control mechanisms for fatty acid synthesis in Mycobacterium smegmatis.
- Crystal Structure of the Mycobacterium tuberculosisβ-Ketoacyl-Acyl Carrier Protein Synthase III*
- Identification and substrate specificity of beta -ketoacyl (acyl carrier protein) synthase III (mtFabH) from Mycobacterium tuberculosis.
- Mycobacterium smegmatis fatty acid synthetase. Long chain transacylase chain length specificity.
- Mycolic acid biosynthesis and enzymic characterization of the beta-ketoacyl-ACP synthase A-condensing enzyme from Mycobacterium tuberculosis.
- Inhibition of -Ketoacyl-Acyl Carrier Protein Synthase III (FabH) by Acyl-Acyl Carrier Protein in Escherichia coli(*)
- Molecular modeling and simulation of Mycobacterium tuberculosis cell wall permeability.
- Product diversity and regulation of type II fatty acid synthases.
- Crystallography & NMR system: A new software suite for macromolecular structure determination.
- The CCP4 suite: programs for protein crystallography.
- Comparative cell wall core biosynthesis in the mycolated pathogens, Mycobacterium tuberculosis and Corynebacterium diphtheriae.
- Mechanism of Chalcone Synthase
- Macrophages, mycobacteria and HIV: the role of cytokines in determining mycobacterial virulence and regulating viral replication.
- Improved methods for building protein models in electron density maps and the location of errors in these models.
- The 1.8 A crystal structure and active-site architecture of beta-ketoacyl-acyl carrier protein synthase III (FabH) from escherichia coli.
- The Solution Structure of Acyl Carrier Protein from Mycobacterium tuberculosis *
- A polyketide synthase catalyzes the last condensation step of mycolic acid biosynthesis in mycobacteria and related organisms
- The Biosynthesis of Mycolic Acids in Mycobacterium tuberculosis
- Crystal structure of beta-ketoacyl-acyl carrier protein synthase III. A key condensing enzyme in bacterial fatty acid biosynthesis.
Cited by
- Enzymatic Control of the Related Pathways of Fatty Acid and Undecylprodiginine Biosynthesis in Streptomyces coelicolor
- Molecular and biochemical characterisation of novel glycosyltransferases in Mycobacterium tuberculosis
- Tuberculosis: laboratory diagnosis and treatment strategies.
- Interactions of mtFabH with its Substrates and Inhibitors Reveal Novel Mechanistic Insights
- The Mycobacterium tuberculosis FAS‐II condensing enzymes: their role in mycolic acid biosynthesis, acid‐fastness, pathogenesis and in future drug development
- Diversion of phagosome trafficking by pathogenic Rhodococcus equi depends on mycolic acid chain length
- Fatty acid biosynthesis in actinomycetes
- Synthesis, In Vitro Antitubercular Activity and 3D‐QSAR of Novel Quinoxaline Derivatives
- The Molecular Genetics of Mycolic Acid Biosynthesis
- Pathogenesis in tuberculosis: transcriptomic approaches to unraveling virulence mechanisms and finding new drug targets.
- Flavonoid inhibitors as novel antimycobacterial agents targeting Rv0636, a putative dehydratase enzyme involved in Mycobacterium tuberculosis fatty acid synthase II.
- Streptomyces coelicolor RedP and FabH enzymes, initiating undecylprodiginine and fatty acid biosynthesis, exhibit distinct acyl-CoA and malonyl-acyl carrier protein substrate specificities.
- Detection and Confirmation of Alkaloids in Leaves of Justicia adhatoda and Bioinformatics Approach to Elicit Its Anti-tuberculosis Activity
- Synthesis and biological evaluation of a C5-biphenyl thiolactomycin library.
- A ketosynthase homolog uses malonyl units to form esters in cervimycin biosynthesis.
- Separate entrance and exit portals for ligand traffic in Mycobacterium tuberculosis FabH.
- Alkyl-CoA disulfides as inhibitors and mechanistic probes for FabH enzymes.
- Structure of FabH and factors affecting the distribution of branched fatty acids in Micrococcus luteus.
- Identification of 2-Aminothiazole-4-Carboxylate Derivatives Active against Mycobacterium tuberculosis H37Rv and the β-Ketoacyl-ACP Synthase mtFabH
- The Condensing Activities of the Mycobacterium tuberculosis Type II Fatty Acid Synthase Are Differentially Regulated by Phosphorylation*
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