Regulation of immunity by lysosphingolipids and their G protein-coupled receptors.
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Summary
T and B lymphocytes, as well as endothelial cells, express distinctive profiles of G protein-coupled receptors for sphingosine 1-phosphate, which is a major regulator of T cell development, B and T cell recirculation, tissue homing patterns, and chemotactic responses to chemokines.
- Type
- article
- Published
- 2004-12-01
- Cited by
- 141
- References
- 65
- Access
- Open access
- OpenAlex
- https://openalex.org/W15578083
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:29419797
Keywords
Political science, Art
References
- Identification of p2y9/GPR23 as a Novel G Protein-coupled Receptor for Lysophosphatidic Acid, Structurally Distant from the Edg Family*
- FTY720, a novel immunosuppressant possessing unique mechanisms. I. Prolongation of skin allograft survival and synergistic effect in combination with cyclosporine in rats.
- Lysophospholipids and eicosanoids in biology and pathophysiology
- Identification of cDNAs encoding two G protein‐coupled receptors for lysosphingolipids 1
- Specificity of expression and effects of eicosanoid mediators in normal physiology and human diseases 1
- An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors.
- FTY720 Immunosuppression Impairs Effector T Cell Peripheral Homing Without Affecting Induction, Expansion, and Memory1
- Sphingosine-1-Phosphate Receptor Agonism Impairs the Efficiency of the Local Immune Response by Altering Trafficking of Naive and Antigen-Activated CD4+ T Cells
- Sphingosylphosphorylcholine is a ligand for ovarian cancer G-protein-coupled receptor 1
- The Generation of Mature, Single-Positive Thymocytes In Vivo Is Dysregulated by CD69 Blockade or Overexpression1
- FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. I. FTY720 selectively decreases the number of circulating mature lymphocytes by acceleration of lymphocyte homing.
- Effect of FTY720, a novel immunosuppressant, on adjuvant- and collagen-induced arthritis in rats.
- Characterization of a Novel Subtype of Human G Protein-coupled Receptor for Lysophosphatidic Acid*
- Sphingosine 1-phosphate receptor 1 promotes B cell localization in the splenic marginal zone
- Proton-sensing G-protein-coupled receptors
- The immunosuppressant FTY720 down‐regulates sphingosine 1‐phosphate G protein‐coupled receptors
- Phosphorylation and Action of the Immunomodulator FTY720 Inhibits Vascular Endothelial Cell Growth Factor-induced Vascular Permeability*
- Interaction of sphingosine 1-phosphate with plasma components, including lipoproteins, regulates the lipid receptor-mediated actions.
- Sphingosine 1-phosphate and control of vascular tone.
- Activation‐regulated expression and chemotactic function of sphingosine 1‐phosphate receptors in mouse splenic T cells
Cited by
- Normal acute and chronic inflammatory responses in sphingosine kinase 1 knockout mice
- The Sphingosine 1-Phosphate Signaling Pathway in Epilepsy: A Possible Role for the Immunomodulator Drug Fingolimod in Epilepsy Treatment.
- Crosstalk between Fas and S1P1 signaling via NF-kB in osteoclasts controls bone destruction in the TMJ due to rheumatoid arthritis
- Regulation of Invasiveness of Glioblastoma Multiforme Cell Lines and Tumor Stem Cells by Sphingosine Kinase and Sphingosine 1-Phosphate Reveals Potential Molecular Therapeutic Targets
- Étude de l’homéostasie lymphocytaire B dans la physiopathologie de la sclérose en plaques : de l’approche expérimentale à l’Homme
- Molecular mechanisms involved in oligodendrocyte development
- Functional analysis of TOR complex 2 and its control of sphingolipid biosynthesis in "Saccharomyces cerevisiae"
- The Role of Acid Sphingomyelinase in Experimental Autoimmune Encephalomyelitis
- Sphingosine 1‐phosphate as an intracellular messenger and extracellular mediator in immunity
- Regulation of immune function by G protein-coupled receptors, trimeric G proteins, and RGS proteins.
- Lysophosphatidic Acid (LPA) Receptor 5 Inhibits B Cell Antigen Receptor Signaling and Antibody Response
- Die Bedeutung des Sphingolipidstoffwechsels für die Generierung von inflammatorischen und fibrotischen Mediatoren in renalen Mesangiumzellen
- Autotaxin through lysophosphatidic acid stimulates polarization, motility, and transendothelial migration of naïve T cells
- A ceramide‐1‐phosphate analogue, PCERA‐1, simultaneously suppresses tumour necrosis factor‐α and induces interleukin‐10 production in activated macrophages
- Inhibitory Role of Sphingosine 1-Phosphate Receptor 2 in Macrophage Recruitment during Inflammation
- FTY720 Ameliorates Th1-Mediated Colitis in Mice by Directly Affecting the Functional Activity of CD4+CD25+ Regulatory T Cells1
- Role of Sphingosine 1-Phosphate in the Pathogenesis of Sjögren’s Syndrome1
- The Spleen Responds to Intestinal Manipulation but Does Not Participate in the Inflammatory Response in a Mouse Model of Postoperative Ileus
- Signal Transduction of Sphingosine-1-Phosphate G Protein—Coupled Receptors
- Sphingosine 1‐Phosphate Interferes on the Differentiation of Human Monocytes into Competent Dendritic Cells
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