Lipid metabolism in hepatic steatosis.
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Summary
While increased hepatic LCFA uptake contributes to the pathogenesis of both NASH and alcoholic hepatitis, the underlying mechanisms differ and recognizing these mechanistic differences is important in developing strategies for both prevention and treatment of these conditions.
- Type
- dissertation
- Published
- 2004-08-01
- Cited by
- 125
- References
- 174
- Access
- Open access
- OpenAlex
- https://openalex.org/W15331068
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:6773808
Keywords
Grid computing, Grid, Computer science, Computer security, Distributed computing
References
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- Molecular Cell Biology
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- Adipocyte differentiation of 3T3-L1 cells involves augmented expression of a 43-kDa plasma membrane fatty acid-binding protein.
- Overweight and obesity in the United States: prevalence and trends, 1960–1994
- Constitutive expression of a saturable transport system for non-esterified fatty acids in Xenopus laevis oocytes.
- Localization and regulation of the putative membrane fatty-acid transporter (FAT) in the small intestine. Comparison with fatty acid-binding proteins (FABP).
- Sex differences in hepatic fatty acid uptake reflect a greater affinity of the transport system in females.
- Regulation of stearoyl-CoA desaturase by polyunsaturated fatty acids and cholesterol.
Cited by
- Effects of carbon dioxide pneumoperitoneum on hepatic and renal morphology of rats after segmental colectomy and colonic anastomosis.
- Thyroid hormone analogues and derivatives: Actions in fatty liver.
- Increased hepatocellular uptake of long chain fatty acids occurs by different mechanisms in fatty livers due to obesity or excess ethanol use, contributing to development of steatohepatitis in both settings.
- Effects of Weight Loss on Adipose Tissue, Liver and Heart Metabolism in Humans
- Factors determining the progression of nonalcoholic fatty liver disease : the role of abnormal fatty acid and glucocorticoid metabolism
- The effects of different types of dietary fats in the liver
- Estrogen withdrawal and liver fat accumulation : contribution of hepatic VLDL-TG production and effect of exercise training
- Mouse models in non‐alcoholic fatty liver disease and steatohepatitis research
- Hepatic lipid metabolism changes in short- and long-term prehepatic portal hypertensive rats.
- Palmitic acid induced lipotoxicity is associated with altered lipid metabolism, enhanced CYP450 2E1 and intracellular calcium mediated ER stress in human hepatoma cells
- PPAR/RXR Regulation of Fatty Acid Metabolism and Fatty Acid ω-Hydroxylase (CYP4) Isozymes: Implications for Prevention of Lipotoxicity in Fatty Liver Disease
- Site Specific Delivery of Microencapsulated Fish Oil to the Gastrointestinal Tract of the Rat
- Compound K modulates fatty acid‐induced lipid droplet formation and expression of proteins involved in lipid metabolism in hepatocytes
- Chronic Ethanol Consumption Increases Cardiomyocyte Fatty Acid Uptake and Decreases Ventricular Contractile Function in C57BL/6J Mice
- Obesity and Its Metabolic Complications: The Role of Adipokines and the Relationship between Obesity, Inflammation, Insulin Resistance, Dyslipidemia and Nonalcoholic Fatty Liver Disease
- Fructose as a key player in the development of fatty liver disease.
- Impairment of Hepatic Growth Hormone and Glucocorticoid Receptor Signaling Causes Steatosis and Hepatocellular Carcinoma in Mice
- Hepatoprotective role of Abelmoschus esculentus (Linn.) Moench., on carbon tetrachloride-induced liver injury
- Adipocyte Accumulation of Long-Chain Fatty Acids in Obesity is Multifactorial, Resulting from Increased Fatty Acid Uptake and Decreased Activity of Genes Involved in Fat Utilization
- Mechanism-based selection of compounds for the development of innovative in vitro approaches to hepatotoxicity studies in the LIINTOP project.
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