Intrinsic activity and comparative molecular dynamics of buspirone analogues at the 5-HT(1A) receptors.
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Summary
The predicted receptor-ligand interactions indicated similarities in the receptor binding modes for all buspirone analogues, and no clear relationship between receptor contact residues and activity at pre- and post-synaptic receptors.
- Type
- article
- Published
- 2004-06-15
- Cited by
- 14
- References
- 45
- OpenAlex
- https://openalex.org/W15163553
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:7711996
Keywords
Philosophy, Epistemology
References
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- A well-behaved electrostatic potential-based method using charge restraints for deriving atomic char
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- Ligand induced conformational states of the 5-HT(1A) receptor.
- Molecular Mechanisms Involved in Muscarinic Acetylcholine Receptor-mediated G Protein Activation Studied by Insertion Mutagenesis (*)
- Mapping the Binding Site Pocket of the Serotonin 5-Hydroxytryptamine2A Receptor
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Cited by
- Synthesis and biological investigation of potential atypical antipsychotics with a tropane core. Part 1.
- Stereoselectivity of 8-OH-DPAT toward the serotonin 5-HT1A receptor: biochemical and molecular modeling study.
- Buspirone transdermal administration for menopausal syndromes, in vitro and in animal model studies.
- Model structure–activity relationship studies of potential tropane 5HT1A, 5HT2A, and D2 receptor ligands
- N-[4-(arylpiperazin-1-yl)butyl]bicyclo[2.2.1]hept-5-ene-endo-2,endo-3-dicarboximides and Their Epoxy Derivatives. Synthesis and affinity for 5-HT1a receptors
- Synthesis and biological evaluation of novel pyrrolidine-2,5-dione derivatives as potential antidepressant agents. Part 1.
- Treatment of cognitive dysfunction in chronic schizophrenia by augmentation of atypical antipsychotics with buspirone, a partial 5‐HT1A receptor agonist
- Update 1 of: computational modeling approaches to structure-function analysis of G protein-coupled receptors.
- From Homology Models to a Set of Predictive Binding Pockets – a 5-HT1A Receptor Case Study
- Recognition of repulsive and attractive regions of selected serotonin receptor binding site using FMO-EDA approach
- Design, synthesis and biological evaluation of novel serotonin and dopamine receptor ligands being 6-bromohexyl saccharine derivatives.
- MODELE ODDZIAŁYWAŃ LIGANDÓW ARYLOPIPERAZYNYLOWYCH Z RECEPTORAMI SEROTONINOWYMI 5-HT1A, 5-HT2A I 5-HT7
- An overview of the efficacy and safety of brexpiprazole for the treatment of schizophrenia in adolescents
- Structure and Function Reveal Insights in the Pharmacology of 5-HT Receptor Subtypes
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