Triple-nucleoside regimens versus efavirenz-containing regimens for the initial treatment of HIV-1 infection.
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Summary
In this trial of the initial treatment of HIV-1 infection, the triple-nucleoside combination of abacavir, zidovudine, and lamivudine was virologically inferior to a regimen containing efavirenz and two or three nucleosides.
- Type
- article
- Published
- 2004-04-29
- Cited by
- 535
- References
- 47
- Access
- Open access
- OpenAlex
- https://openalex.org/W15115831
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:22253836
Keywords
Riparian zone, Arid, Geography, Environmental science, Agroforestry
References
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- Adherence to protease inhibitors, HIV-1 viral load, and development of drug resistance in an indigent population
- Impact of protease inhibitors on AIDS‐defining events and hospitalizations in 10 French AIDS reference centres
- Discrete sequential boundaries for clinical trials
- Hyperlipidemia and Insulin Resistance Are Induced by Protease Inhibitors Independent of Changes in Body Composition in Patients With HIV Infection
- Adherence to highly active antiretroviral therapy is better in patients receiving non-nucleoside reverse transcriptase inhibitor-containing regimens than in those receiving protease inhibitor-containing regimens.
- Overview of the effectiveness of triple combination therapy in antiretroviral-naive HIV-1 infected adults
- Design and analysis of randomized clinical trials requiring prolonged observation of each patient. I. Introduction and design.
- Time trends in primary HIV-1 drug resistance among recently infected persons.
- A multiple testing procedure for clinical trials.
- Treatment with protease inhibitors associated with peripheral insulin resistance and impaired oral glucose tolerance in HIV‐1‐infected patients
- Combining dependent tests with incomplete repeated measurements
- Group Sequential Methods with Applications to Clinical Trials
- Treatment‐Related Factors and Highly Active Antiretroviral Therapy Adherence
- The Statistical Analysis of Failure Time Data
- Twice-daily triple nucleoside intensification treatment with lamivudine-zidovudine plus abacavir sustains suppression of human immunodeficiency virus type 1: results of the TARGET Study.
- Response to lamivudine-zidovudine plus abacavir twice daily in antiretroviral-naive, incarcerated patients with HIV infection taking directly observed treatment.
- Human Immunodeficiency Virus Type 1 Mutations Selected in Patients Failing Efavirenz Combination Therapy
Cited by
- An Improvement in Virologic Response to Highly Active Antiretroviral Therapy in Clinical Practice From 1996 Through 2002
- Highly active antiretroviral therapy (HAART) in adults with tuberculosis: current status.
- Effectiveness and Safety of Abacavir, Lamivudine, and Zidovudine in Antiretroviral Therapy-Naive HIV-Infected Patients: Results From a Large Multicenter Observational Cohort
- Highly active anti‐retroviral therapy (HAART)‐induced maintenance of adaptive but not innate immune parameters is associated with protection from HIV‐induced mortality
- Metabolic Effects of Protease Inhibitor-Sparing Antiretroviral Regimens Given as Initial Treatment of HIV-1 Infection (AIDS Clinical Trials Group Study A5095)
- Pediatric HIV infection: the state of antiretroviral therapy
- Clinical audit: virological and immunological response to combination antiretroviral therapy in HIV patients at a Sydney sexual health clinic
- Comparative effectiveness of continuing a virologically effective first-line boosted protease inhibitor combination or of switching to a three-drug regimen containing either efavirenz, nevirapine or abacavir.
- Enhanced identification of synergistic and antagonistic emergent interactions among three or more drugs
- Evolution of Resistance Mutations during Low-Level Viral Replication in HIV-1–Infected Patients Treated with Zidovudine/Lamivudine/Abacavir as a First-Line Regimen
- Interpretation of resistance data from randomized trials of first-line antiretroviral treatment.
- Virological response to a triple nucleoside/nucleotide analogue regimen over 48 weeks in HIV-1-infected adults in Africa
- Effect of Nucleoside and Nucleotide Reverse Transcriptase Inhibitors of HIV on Endogenous Nucleotide Pools
- Lack of a Metabolic and Antiviral Drug Interaction between Tenofovir, Abacavir and Lamivudine
- Antiretroviral (ARV) drug resistance in the developing world.
- Relationship between Minority NNRTI Resistance Mutations, Adherence, and the Risk of Virologic Failure
- Antiretroviral Therapy: Current Drugs
- [Antiviral treatment regimens].
- Management of individuals requiring ART and TB treatment
- Analysis of neuropsychiatric adverse events during clinical trials of efavirenz in antiretroviral-naive patients: a systematic review.
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