Chronic Hypercortisolemia Inhibits Dopamine Synthesis and Turnover in the Nucleus accumbens: An in vivo Microdialysis Study
Explore this paper's citation graph
Summary
Results indicate that CORT inhibits DA synthesis and turnover in the NAc but not in the PFC, and region-specific CORT-induced inhibition of DAergic activity may help to explain depressive symptoms in patients with chronichypercortisolemia and normalization after medical or surgical correction of hypercortisolism.
- Type
- article
- Published
- 2002-09-01
- Cited by
- 44
- References
- 81
- OpenAlex
- https://openalex.org/W12218347
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:2797639
Keywords
Geography, Humanities, Institution, Archaeology, Art
References
- Catecholamine innervation of the basal forebrain III. Olfactory bulb, anterior olfactory nuclei, olfactory tubercle and piriform cortex
- Biochemistry of Somatodendritic Dopamine Release in Substantia Nigra: An In Vivo Comparison with Striatal Dopamine Release
- Individual differences in stress‐induced dopamine release in the nucleus accumbens are influenced by corticosterone
- Increased catecholamine levels in specific brain regions of a rat model of depression: normalization by chronic antidepressant treatment.
- Electrical stimulation of the prefrontal cortex increases dopamine release in the nucleus accumbens of the rat: modulation by metabotropic glutamate receptors
- Mesocorticolimbic dopaminergic network: functional and regulatory roles.
- Improved assay for plasma dihydroxyphenylacetic acid and other catechols using high-performance liquid chromatography with electrochemical detection.
- The dopaminergic hyper‐responsiveness of the shell of the nucleus accumbens is hormone‐dependent
- The role of nucleus accumbens dopamine in motivated behavior: a unifying interpretation with special reference to reward-seeking.
- The mesolimbic dopamine system as a target for rapid antidepressant action
- The effects of a single acute dose of dexamethasone on monoamine and metabolite levels in rat brain.
- Reciprocal changes in prefrontal and limbic dopamine responsiveness to aversive and rewarding stimuli after chronic mild stress: implications for the psychobiology of depression.
- Catecholaminergic inhibition by hypercortisolemia in the paraventricular nucleus of conscious rats.
- Opposed Behavioural Outputs of Increased Dopamine Transmission in Prefrontocortical and Subcortical Areas: A Role for the Cortical D‐1 Dopamine Receptor
- Genotype-dependent effects of chronic stress on apomorphine-induced alterations of striatal and mesolimbic dopamine metabolism.
- In vivo hypothalamic release and synthesis of catecholamines in spontaneously hypertensive rats.
- The endocrinology of melancholic and atypical depression: relation to neurocircuitry and somatic consequences.
- The role of stress in the pathophysiology of the dopaminergic system
- Effects of acute and chronic administration of high-dose corticosterone and dexamethasone on regional brain dopamine and serotonin metabolism in rats.
- The role of monoamine neurotransmitter systems in the nicotine discriminative stimulus.
Cited by
- Children experience cognitive decline despite reversal of brain atrophy one year after resolution of Cushing syndrome.
- DOPAMINE IN THE RAT NUCLEUS ACCUMBENS CORE: PATCHWORK OF DOMAINS AND PREFERENTIAL EFFECTS OF NOMIFENSINE
- CRH, stress, and major depression: a psychobiological interplay.
- The Influence of Stress on the Transition From Drug Use to Addiction
- Modulación del sistema nitrérgico por nicotina: estudio con ratones mutantes
- Stress, alcohol and drug interaction: an update of human research
- Ejes neuroendocrinos del estrés, síndrome metabólico y alteraciones psiquiátricas del síndrome de Cushing
- Intra-nucleus-accumbens SKF38393 improved the impaired acquisition of morphine-conditioned place preference in depression-like rats.
- Adverse childhood experiences (ACEs), genetic polymorphisms and neurochemical correlates in experimentation with psychotropic drugs among adolescents.
- Long‐term negative impact on quality of life in patients with successfully treated Cushing's disease
- PTSD Symptoms, Potentially Traumatic Event Exposure, and Binge Drinking: A Prospective Study with a National Sample of Adolescents
- Effects of acute diuresis stress on egr-1 (zif268) mRNA levels in brain regions associated with motivated behavior.
- Role of glucocorticoids in dopamine-related neuropsychiatric disorders.
- The serotonin-dopamine interaction is critical for fast-onset action of antidepressant treatment: in vivo studies in an animal model of depression.
- The effect of dexamethasone on gliosis, ischemia, and dopamine extraction during microdialysis sampling in brain tissue
- Toward an integrative model of the spectrum of mood, behavioral and personality disorders based on fear and anger traits: II. Implications for neurobiology, genetics and psychopharmacological treatment.
- Role of Gamma-Aminobutyric Acid Neurons in the Release of Gonadotropin-Releasing Hormone in Cultured Rat Embryonic Olfactory Placodes
- Predictors of mortality and long-term outcomes in treated Cushing's disease: a study of 346 patients.
- Endocrine withdrawal syndromes.
- Antithyroid medications and psychosis
Related papers
No related papers recorded.