Adult-onset calorie restriction and fasting delay spontaneous tumorigenesis in p53-deficient mice.
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Summary
It is found that CR or a 1 day/week fast suppressed carcinogenesis-even when started late in life in mice predestined to develop tumors due to decreased p53 gene dosage-support efforts to identify suitable interventions influencing energy balance in humans as a tool for cancer prevention.
- Type
- article
- Published
- 2002-05-01
- Cited by
- 214
- References
- 32
- OpenAlex
- https://openalex.org/W12016155
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:20699989
Keywords
Computer science, Task (project management), Transfer of learning, Artificial intelligence, Machine learning
References
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Cited by
- Diet manipulation and prevention of aging, cancer and autoimmune disease
- Establishing a role for specific nutrients in Drosophila dietary restriction
- Role of prevention: cost-effectiveness of prevention.
- Energy restriction for breast cancer prevention.
- Combination of physical activity, nutrition, or other metabolic factors and vaccine response.
- Calories and Longevity: Do They Really Matter?
- Molecular damage in cancer: an argument for mTOR-driven aging
- Regulating Mechanisms of Gonadal and Pituitary Tumorigenesis in Mice Producing Human Chorionic Gonadotropin
- Can short-term dietary restriction and fasting have a long-term anticarcinogenic effect?
- Rapamycin extends life- and health span because it slows aging
- Mechanisms of dietary restriction in aging and disease.
- Suppression of Carcinogenesis and Tumor Progression by an Energy Restriction-Mimetic Agent in Murine Models of Prostate Cancer
- Food Restriction Prolongs Murine Cardiac Grafts.
- Phenotypic effects of calorie restriction and insulin-like growth factor-1 treatment on body composition and bone mineral density of C57BL/6 mice: implications for cancer prevention.
- Effects of energy balance on cancer in genetically altered mice.
- Prevalence of obese dogs in a population of dogs with cancer.
- Metabolic regulation of sirtuins upon fasting and the implication for cancer
- Rapamycin-induced glucose intolerance: Hunger or starvation diabetes
- Adult-onset calorie restriction attenuates kainic acid excitotoxicity in the rat hippocampal slice.
- Effect of caloric restriction on Hprt lymphocyte mutation in aging rats.
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