Stress, mixed messages, and hormone signaling : regulation of translation and the unfolded protein response in pituitary gonadotropes
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Summary
This body of work blends the fields of reproductive endocrinology and translational control to provide a novel physiological function for the UPR and establish that GnRH exerts specific and bidirectional regulation of translation.
- Type
- article
- Published
- 2008-01-01
- Cited by
- 0
- References
- 129
- OpenAlex
- https://openalex.org/W10547811
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:81738330
Keywords
Gonadotropic cell, Gonadotropin-releasing hormone, Biology, Unfolded protein response, Anterior pituitary
References
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- BiP, a Major Chaperone Protein of the Endoplasmic Reticulum Lumen, Plays a Direct and Important Role in the Storage of the Rapidly Exchanging Pool of Ca2+ *
- Translation control: bridging the gap between genomics and proteomics?
- ERK and p38 Inhibit the Expression of 4E-BP1 Repressor of Translation through Induction of Egr-1*
- Regulation of translation initiation factors by signal transduction.
- Characterization of phosphopeptides from protein digests using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and nanoelectrospray quadrupole time-of-flight mass spectrometry.
- The pituitary effects of GnRH.
- Constitutively active Gq impairs gonadotropin-releasing hormone-induced intracellular signaling and luteinizing hormone secretion in LbetaT2 cells.
- Ribonucleoprotein infrastructure regulating the flow of genetic information between the genome and the proteome
- Adaptation to ER Stress Is Mediated by Differential Stabilities of Pro-Survival and Pro-Apoptotic mRNAs and Proteins
- Pituitary gonadotropin-releasing hormone (GnRH) receptor: structure, distribution and regulation of expression.
- Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis.
- Pulsatile gonadotropin-releasing hormone modifies polyadenylation of gonadotropin subunit messenger ribonucleic acids.
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