Levels of HIV‐infected peripheral blood cells remain stable throughout the natural history of HIV‐1 infection
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Summary
Levels of provirus-bearing PBMC remain constant during the natural course of HIV-1 infection, whereas plasma virus load typically increases logarithmically during the same period, suggesting that plasma virus levels are directly related to the number of infected cells may deserve reconsideration.
- Type
- article
- Published
- 1998-11-01
- Cited by
- 41
- References
- 37
- OpenAlex
- https://openalex.org/W2093134334
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25790636
Keywords
Provirus, Peripheral blood mononuclear cell, Seroconversion, Immunology, Natural history
References
- Viral dynamics in human immunodeficiency virus type 1 infection
- Quantitative Analysis of HIV-1 Proviral DNA in Peripheral Blood Mononuclear Cells from Patients with AIDS or ARC: Decrease of Proviral DNA Content Following Treatment with 2′,3′-Dideoxyinosine (ddI)
- Peripheral blood mononuclear cell human immunodeficiency virus type 1 proviral DNA quantification by polymerase chain reaction: relationship to immunodeficiency and drug effect
- Absolute quantitation of viremia in human immunodeficiency virus infection by competitive reverse transcription and polymerase chain reaction
- A comprehensive genetic map of the human genome based on 5,264 microsatellites
- Variable relationship between proviral DNA load and infectious virus titre in the peripheral blood mononuclear cells of HIV‐1‐infected individuals
- A simple procedure for optimising the polymerase chain reaction (PCR) using modified Taguchi methods.
- Increasing viral burden in CD4+ T cells from patients with human immunodeficiency virus (HIV) infection reflects rapidly progressive immunosuppression and clinical disease.
- HIV Type 2 Proviral Load Measured by Quantitative Polymerase Chain Reaction Correlates with CD4+ Lymphopenia in HIV Type 2-Infected Individuals
- Antiretroviral Therapy Is Associated with a Decrease in Unintegrated HIV‐1 DNA in Pediatric Patients
- Evaluation of proviral copy number and plasma RNA level as early indicators of progression in HIV‐1 infection: correlation with virological and immunological markers of disease
- Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection
- HIV-1 Dynamics in Vivo: Virion Clearance Rate, Infected Cell Life-Span, and Viral Generation Time
- Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection
- A model for treatment strategy in the chemotherapy of AIDS.
- Decay characteristics of HIV-1-infected compartments during combination therapy
- HIV viral load markers in clinical practice
- High levels of HIV-1 in plasma during all stages of infection determined by competitive PCR.
- Detection of HIV-1 Distribution in Different Blood Fractions by Two Nucleic Acid Amplification Assays
- Anti-viral drug treatment: dynamics of resistance in free virus and infected cell populations.
Cited by
- Delayed HIV‐1 Infection of CD4+ T Lymphocytes from Therapy‐Naïve Patients Demonstrated by Quantification of HIV‐1 DNA Copy Numbers
- HIV-1 DNA for the measurement of the HIV reservoir is predictive of disease progression in seroconverters whatever the mode of result expression is.
- Simian Immunodeficiency Virus Replicates to High Levels in Naturally Infected African Green Monkeys without Inducing Immunologic or Neurologic Disease
- Dynamics of Viral Load in Plasma and HIV DNA in Lymphocytes During Highly Active Antiretroviral Therapy (HAART): High Viral Burden in Macrophages after 1 Year of Treatment
- Productive Infection Maintains a Dynamic Steady State of Residual Viremia in Human Immunodeficiency Virus Type 1-Infected Persons Treated with Suppressive Antiretroviral Therapy for Five Years
- Cell-associated HIV DNA Measured Early During Infection has Prognostic Value Independent of Serum HIV RNA Measured Concomitantly
- Kinetics of Early FIV Infection in Cats Exposed via the Vaginal versus Intravenous Route
- Impact of HIV Type 1 DNA Levels on Spontaneous Disease Progression: A Meta-Analysis
- HIV Type 1 DNA Development during Long-Term Supervised Therapy Interruption
- HIV RNA and HIV DNA in Peripheral Blood Mononuclear Cells Are Consistent Markers for Estimating Viral Load in Patients Undergoing Long-Term Potent Treatment
- Factors influencing peripheral blood mononuclear cell-associated HIV-1 DNA level after long-term suppressive antiretroviral therapy in 236 patients
- Initiation of Antiretroviral Therapy During Recent HIV-1 Infection Results in Lower Residual Viral Reservoirs
- Virological and immunological profiles among patients with undetectable viral load followed prospectively for 24 months
- Proviral HIV-1 DNA in subjects followed since primary HIV-1 infection who suppress plasma viral load after one year of highly active antiretroviral therapy
- Long-Term Effects of Antiretroviral Combination Therapy on HIV Type 1 DNA Levels
- A multiplex real‐time PCR for quantification of HIV‐1 DNA and the human albumin gene in CD4+ cells
- HIV-1 DNA Burden in Peripheral Blood CD4+ Cells Influences Disease Progression, Antiretroviral Efficacy, and CD4+ T-Cell Restoration
- Equal plasma viral loads predict a similar rate of CD4+ T cell decline in human immunodeficiency virus (HIV) type 1- and HIV-2-infected individuals from Senegal, West Africa.
- Change in plasma viral load, and viral DNA and mRNA burdens, in peripheral blood mononuclear cells from patients infected with HIV-1.
- Low Plasma Human Immunodeficiency Virus Type 2 Viral Load Is Independent of Proviral Load: Low Virus Production In Vivo
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