The effect of subantimicrobial-dose-doxycycline periodontal therapy on serum biomarkers of systemic inflammation: a randomized, double-masked, placebo-controlled clinical trial
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Summary
A two-year SDD regimen in postmenopausal women with chronic periodontitis significantly reduced the serum inflammatory biomarkers hs-CRP and MMP-9 and, among women more than five years postmenopausal, raised HDL cholesterol.
- Type
- article
- Published
- 2011-03-01
- Cited by
- 85
- References
- 44
- Access
- Open access
- OpenAlex
- https://openalex.org/W9720479
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:19434954
Keywords
Medicine, Systemic inflammation, Internal medicine, Periodontitis, Regimen
References
- Human monocyte-derived macrophages induce collagen breakdown in fibrous caps of atherosclerotic plaques. Potential role of matrix-degrading metalloproteinases and implications for plaque rupture.
- Genetic Loci Influencing C-reactive Protein Levels and Risk of Coronary Heart Disease
- Antibiotic use and risk of myocardial infarction.
- Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial.
- Effects of scaling and root planing and sub-antimicrobial dose doxycycline on oral and systemic biomarkers of disease in patients with both chronic periodontitis and coronary artery disease.
- Discrete sequential boundaries for clinical trials
- Relationship of destructive periodontal disease to the acute-phase response.
- Subantimicrobial dose doxycycline effects on alveolar bone loss in post-menopausal women.
- Treatment of early seropositive rheumatoid arthritis: doxycycline plus methotrexate versus methotrexate alone.
- Airway Obstruction Correlates with Collagenase-2 (MMP-8) Expression and Activation in Bronchial Asthma
- Comparison of levels of serum matrix metalloproteinase-9 in patients with acute myocardial infarction versus unstable angina pectoris versus stable angina pectoris.
- Clinical trials with multiple outcomes: a statistical perspective on their design, analysis, and interpretation.
- MMPs, IL-1, and TNF are Regulated by IL-17 in Periodontitis
- Efficacy of sub-antimicrobial dose doxycycline in post-menopausal women: clinical outcomes.
- Treatment with subantimicrobial dose doxycycline improves the efficacy of scaling and root planing in patients with adult periodontitis.
- Collagenase-2 (MMP-8) as a point-of-care biomarker in periodontitis and cardiovascular diseases. Therapeutic response to non-antimicrobial properties of tetracyclines.
- Circulating Matrix Metalloproteinase-9 Is Associated with Cardiovascular Risk Factors in a Middle-Aged Normal Population
- C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women.
- Subantimicrobial-Dose Doxycycline Modulates Gingival Crevicular Fluid Biomarkers of Periodontitis in Postmenopausal Osteopenic Women
- A nonantibiotic chemically modified tetracycline (CMT-3) inhibits intimal thickening.
Cited by
- Matrix metalloproteinases and their tissue inhibitor after reperfused ST-elevation myocardial infarction treated with doxycycline. Insights from the TIPTOP trial.
- Subgingival delivery of oral debriding agents: a proof of concept.
- Effects of doxycycline on local and systemic inflammation in stable COPD patients, a randomized clinical trial.
- Biotic acts of antibiotics
- Proteomics in aortic aneurysm – What have we learnt so far?
- The Link Between Periodontitis and Rheumatoid Arthritis: A Periodontist’s Perspective
- Doxycycline prevents matrix remodeling and contraction by trichiasis-derived conjunctival fibroblasts.
- The PBRN Initiative
- Efficacy of subantimicrobial-dose doxycycline against nitrosative stress in chronic periodontitis
- Non-antibacterial tetracycline formulations: clinical applications in dentistry and medicine
- Matrix metalloproteinases: targets for doxycycline to prevent the vascular alterations of hypertension.
- Antioxidant Response of Osteoblasts to Doxycycline in an Inflammatory Model Induced by C-reactive Protein and Interleukin-6
- Non-anti-infective effects of antimicrobials and their clinical applications: a review.
- Response to Bretz review J Evid Base Dent Pract 2011;11:194-195.
- The effect of prolonged systemic doxycycline therapy on serum tissue degrading proteinases in coronary bypass patients: a randomized, double-masked, placebo-controlled clinical trial
- Doxycycline Reduces Cardiac Matrix Metalloproteinase-2 Activity but Does not Ameliorate Myocardial Dysfunction During Reperfusion in Coronary Artery Bypass Patients Undergoing Cardiopulmonary Bypass
- Correlation between the severity of periodontitis and coronary artery stenosis in a Chinese population.
- Non-antibacterial tetracyclines modulate mediators of periodontitis and atherosclerotic cardiovascular disease: a mechanistic link between local and systemic inflammation.
- Nuclear factor kappa B (NF-κB): a novel cause for diabetes, coronary artery disease and cancer initiation and promotion?
- Subantimicrobial dose doxycycline treatment increases serum cholesterol efflux capacity from macrophages
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