Changing the pH of the external aqueous phase may modulate protein entrapment and delivery from poly(lactide-co-glycolide) microspheres prepared by a w/o/w solvent evaporation method.
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Summary
Reducing the solubility of a protein in the external aqueous phase allows the product of microspheres with a better encapsulation efficiency, although this benefit is provided by a strong adsorption of the protein on microsphere surface.
- Type
- article
- Published
- 1998-07-01
- Cited by
- 52
- References
- 18
- OpenAlex
- https://openalex.org/W9651864
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:37593801
Keywords
Political science, Humanities, Philosophy
References
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- The adsorption of bovine serum albumin on positively and negatively charged polystyrene latices
- Characterization and morphological analysis of a cholecystokinin derivative peptide-loaded poly(lactide-co-glycolide) microspheres prepared by a water-in-oil-in-water emulsion solvent evaporation method
- Biodegradable polymers for use in surgery—polyglycolic/poly(actic acid) homo- and copolymers: 1
- Competitive adsorption of β-lactoglobulin + tween 20 at the oil-water interface
- Effects of counteranion of TRH and loading amount on control of TRH release from copoly(dl-lactic/glycolic acid) microspheres prepared by an in-water drying method
- Adsorption/desorption of human serum albumin at the surface of poly(lactic acid) nanoparticles prepared by a solvent evaporation process.
- Encapsulation of water-soluble drugs by a modified solvent evaporation method. I. Effect of process and formulation variables on drug entrapment.
- Effect of the emulsion stability on the morphology and porosity of semicrystalline poly l-lactide microparticles prepared by w/o/w double emulsion-evaporation
- Protein-loaded poly(dl-lactide-co-glycolide) microparticles for oral administration: formulation, structural and release characteristics
- High-performance liquid chromatography as a technique to measure the competitive adsorption of plasma proteins onto latices
- Characterization of V3 BRU peptide-loaded small PLGA microspheres prepared by a (w1/o)w2 emulsion solvent evaporation method
- Biodegradable microspheres as controlled-release tetanus toxoid delivery systems.
- Somatostatin containing biodegradable microspheres prepared by a modified solvent evaporation method based on W/O/W-multiple emulsions
- Protective immunity against Salmonella typhimurium elicited in mice by oral vaccination with phosphorylcholine encapsulated in poly(DL-lactide-co-glycolide) microspheres
- Biodegradable microcapsules prepared by a w/o/w technique: effects of shear force to make a primary w/o emulsion on their morphology and protein release.
- Enhanced secretory IgA and systemic IgG antibody responses after oral immunization with biodegradable microparticles containing antigen.
Cited by
- pH-sensitive and targeted PLGA-based drug delivery to colorectal cancer
- Spectroscopic studies of the interactions between β-lactoglobulin and bovine submaxillary mucin
- Solvent evaporation as a imposing method for microencapsulation - A review
- Development and characterization of skin permeation retardants and enhancers: A comparative study of levothyroxine‐loaded PNIPAM, PLA, PLGA and EC microparticles
- Microencapsulation of Vaccine Antigens and Adjuvants for Mucosal Targeting
- Nano/micro technologies for delivering macromolecular therapeutics using poly(D,L-lactide-co-glycolide) and its derivatives.
- Functionalized three-arm poly(ε-caprolactone) maleic acid microspheres for controlled protein release
- Poly ε-Caprolactone Microparticles Containing Biosurfactants: Optimization of Formulation Factors
- Effects of process and formulation parameters on characteristics and internal morphology of poly(d,l-lactide-co-glycolide) microspheres formed by the solvent evaporation method.
- l-Cysteine conjugated poly l-lactide nanoparticles containing 5-fluorouracil: formulation, characterization, release and uptake by tissues in vivo
- Improvement of protein loading and modulation of protein release from poly(lactide-co-glycolide) microspheres by complexation of proteins with polyanions
- Poly(ethylene carbonate) microspheres: manufacturing process and internal structure characterization.
- Optimization of the encapsulation and release of beta-lactoglobulin entrapped poly(DL-lactide-co-glycolide) microspheres.
- The encapsulation of ribozymes in biodegradable polymeric matrices.
- Formulation and In Vitro Evaluation of Bisphosphonate Loaded Microspheres for Implantation in Osteolysis
- Physicochemical aspects of drug delivery and release from polymer-based colloids
- Poly(D,L-Lactide-Co-Glycolide) microspheres containing 5-fluorouracil: Optimization of process parameters
- Effect of additives on encapsulation efficiency, stability and bioactivity of entrapped lysozyme from biodegradable polymer particles
- PLA-microparticles formulated by means a thermoreversible gel able to modify protein encapsulation and release without being co-encapsulated.
- Formulation optimization for high drug loading colonic drug delivery carrier
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