Mass Spectrometric Quantification of Markers for Protein Oxidation by Tyrosyl Radical, Copper, and Hydroxyl Radical in Low Density Lipoprotein Isolated from Human Atherosclerotic Plaques*

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Summary

The detection of a selective increase of o,o′-dityrosine in LDL isolated from vascular lesions is consistent with the hypothesis that oxidative damage in human atherosclerosis is mediated in part by tyrosyl radical and does not support a role for free metal ions as catalysts of LDL oxidation in the artery wall.

Type
article
Published
1997-02-07
Cited by
379
References
37
Access
Open access

Keywords

Mental health, Psychiatry, Affect (linguistics), Depression (economics), Ethnic group

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