Mass Spectrometric Quantification of Markers for Protein Oxidation by Tyrosyl Radical, Copper, and Hydroxyl Radical in Low Density Lipoprotein Isolated from Human Atherosclerotic Plaques*
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Summary
The detection of a selective increase of o,o′-dityrosine in LDL isolated from vascular lesions is consistent with the hypothesis that oxidative damage in human atherosclerosis is mediated in part by tyrosyl radical and does not support a role for free metal ions as catalysts of LDL oxidation in the artery wall.
- Type
- article
- Published
- 1997-02-07
- Cited by
- 379
- References
- 37
- Access
- Open access
- OpenAlex
- https://openalex.org/W9013599
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:7727183
Keywords
Mental health, Psychiatry, Affect (linguistics), Depression (economics), Ethnic group
References
- Prooxidant iron and copper, with ferroxidase and xanthine oxidase activities in human atherosclerotic material
- The Metabolic basis of inherited disease
- Detection of hydroxyl radicals by aromatic hydroxylation.
- Dityrosine, a specific marker of oxidation, is synthesized by the myeloperoxidase-hydrogen peroxide system of human neutrophils and macrophages.
- p-Hydroxyphenylacetaldehyde Is the Major Product of L-Tyrosine Oxidation by Activated Human Phagocytes
- The role of sulfur-containing amino acids in superoxide production and modification of low density lipoprotein by arterial smooth muscle cells.
- Protein damage and degradation by oxygen radicals. I. general aspects.
- Tyrosyl radical generated by myeloperoxidase is a physiological catalyst for the initiation of lipid peroxidation in low density lipoprotein.
- Rapid isolation of lipoproteins and assessment of their peroxidation by high-performance liquid chromatography postcolumn chemiluminescence.
- Formation of o-tyrosine and dityrosine in proteins during radiolytic and metal-catalyzed oxidation.
- Dityrosine and tyrosine oxidation products are endogenous markers for the selective proteolysis of oxidatively modified red blood cell hemoglobin by (the 19 S) proteasome.
- Oxygen metabolism and the toxic properties of phagocytes.
- Tyrosyl radical generated by myeloperoxidase catalyzes the oxidative cross-linking of proteins.
- Transition metal ions within human atherosclerotic lesions can catalyse the oxidation of low density lipoprotein by macrophages
- Biologically relevant metal ion‐dependent hydroxyl radical generation An update
- Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids.
- Iron and copper promote modification of low density lipoprotein by human arterial smooth muscle cells in culture.
- Formation of dityrosine cross-links in proteins by oxidation of tyrosine residues.
- Oxidants, antioxidants, and the degenerative diseases of aging.
- Myeloperoxidase, a catalyst for lipoprotein oxidation, is expressed in human atherosclerotic lesions.
Cited by
- Assaying for hydroxyl radicals: hydroxylated terephthalate is a superior fluorescence marker than hydroxylated benzoate.
- Iron overload diminishes atherosclerosis in apoE-deficient mice.
- Secretory peptide hormones are biochemical antioxidants: structure-activity relationship.
- Comparative time-courses of copper-ion-mediated protein and lipid oxidation in low-density lipoprotein.
- 7,8-Dihydroneopterin-mediated protection of low density lipoprotein, but not human macrophages, from oxidative stress
- The Risks of Copper Toxicity Contributing to Cognitive Decline in the Aging Population and to Alzheimer's Disease
- Cardiovascular Redox and Ox Stress Proteomics
- Oxidative Stress and Bioprosthetic Heart Valve Degradation: Mechanisms and Prevention
- Mechanism and inhibition of hypochlorous acid-mediated cell death in human monocyte-derived macrophages.
- Molecular action of vitamin E in lipoprotein oxidation: implications for atherosclerosis.
- Protein oxidative damage.
- Gene therapy of atherosclerosis.
- The content of lipoperoxidation products in normal and atherosclerotic human aorta
- From life to death – the struggle between chemistryand biology during aging: the Maillard reaction as an amplifier of genomic damage
- 一酸化窒素(NO)の検出における高分子化鉄ポルフィリン錯体修飾の炭素電極
- Methods in biological oxidative stress
- Fat-Soluble Vitamins
- Development of multifunctional biopolymeric materials for teatment of decubitus ulcers
- Neue Zugänge zu enantioselektiven lipolytischen Enzymen durch fluoreszenzbasierte Durchmusterung kombinatorischer Bibliotheken
- Quantitative Analysis of amino acid oxidation markers by tandem mass spectrometry
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