Solid dispersions: formulation, characterisation, permeability and genomic evaluation
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Summary
This study investigates the formulation of solid dispersion for a range of poorly water soluble drugs with varying physicochemical properties including paracetamol, sulphamethoxazole, phenacetin, indomethacin, chloramphenicol, phenylbutazone and succinylsulphathiazole and PEG 8000 as a carrier.
- Type
- dissertation
- Published
- 2010-03-01
- Cited by
- 4
- References
- 251
- Access
- Open access
- OpenAlex
- https://openalex.org/W8461569
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:134761202
Keywords
Dissolution, Bioavailability, Solubility, Pharmaceutics, PEG ratio
References
- Transport of parthenolide across human intestinal cells (Caco-2).
- Characterization of Drug Transport Through Tight-Junctional Pathway in Caco-2 Monolayer: Comparison with Isolated Rat Jejunum and Colon
- TM4: a free, open-source system for microarray data management and analysis.
- Comparison of Intestinal Permeabilities Determined in Multiple in Vitro and inSitu Models: Relationship to Absorption in Humans
- Use of a cDNA microarray to analyse gene expression patterns in human cancer
- In Vitro Permeability Through Caco-2 Cells is not Quantitatively Predictive of in Vivo Absorption for Peptide-Like Drugs Absorbed via the Dipeptide Transporter System
- Invitation to Biology
- Intestinal Drug Absorption and Metabolism in Cell Cultures: Caco-2 and Beyond
- STUDIES ON ABSORPTION OF EUTECTIC MIXTURE. II. ABSORPTION OF FUSED CONGLOMERATES OF CHLORAMPHENICOL AND UREA IN RABBITS.
- Selective Paracellular Permeability in Two Models of Intestinal Absorption: Cultured Monolayers of Human Intestinal Epithelial Cells and Rat Intestinal Segments
- A Theoretical Basis for a Biopharmaceutic Drug Classification: The Correlation of in Vitro Drug Product Dissolution and in Vivo Bioavailability
- Parsing free energies of drug-DNA interactions.
- Infrared spectroscopy of biomolecules
- Hydrogen Bonding with Adsorbent During Storage Governs Drug Dissolution from Solid-Dispersion Granules
- Spectroscopic Characterization of Interactions Between PVP and Indomethacin in Amorphous Molecular Dispersions
- Comparison of the Permeability Characteristics of a Human Colonic Epithelial (Caco-2) Cell Line to Colon of Rabbit, Monkey, and Dog Intestine and Human Drug Absorption
- Physicochemical aspects of drug release: X. Investigation of the applicability of the cube root law for characterization of the dissolution rate of fine particulate materials
- In Vitro Permeability Across Caco-2 Cells (Colonic) Can Predict In Vivo (Small Intestinal) Absorption in Man—Fact or Myth
- What is the True Solubility Advantage for Amorphous Pharmaceuticals?
- In Vitro Dissolution Profile Comparison—Statistics and Analysis of the Similarity Factor, f2
Cited by
- Disposition kinetics of diclofenac in the dual perfused rat liver.
- IMPROVING SOLUBILITY OF BCS CLASS II DRUGS USING SOLID DISPERSION: A REVIEW
- Biopharmaceutical classification of poorly soluble drugs with respect to "enabling formulations".
- Investigating the Dissolution and Permeation Properties of Flufenamic Acid Cocrystals
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