Evidence for a bidirectional cross-tolerance between morphine and delta 9-tetrahydrocannabinol in mice.
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Summary
It is indicated that a possible interaction exists between delta 9-tetrahydrocannabinol and the mu-opioid receptors and that a substantial tolerance to analgesic and hypothermic effects of morphine develops in delta 9/9/ cannabinoids-tolerant mice.
- Type
- article
- Published
- 1994-07-21
- Cited by
- 92
- References
- 40
- OpenAlex
- https://openalex.org/W7957626
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:32753262
Keywords
Computer science
References
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Cited by
- Autoradiographic analysis of cannabinoid receptor binding and cannabinoid agonist-stimulated [35S]GTP gamma S binding in morphine-dependent mice.
- Cannabinoids as potential new analgesics.
- Neurochemical basis of cannabis addiction.
- Considering Marijuana Legalization
- Sistema cannabinoide endógeno: ligandos y receptores acoplados a mecanismos de transducción de señales
- Effets comportementaux des cannabinoïdes Données animales
- Estudio de los mecanismos neuronales implicados en las respuestas motivacionales de las drogas de abuso
- Enhancement of morphine actions in morphine-naive and morphine-tolerant mice by LY 235959, a competitive antagonist of the NMDA receptor.
- Repeated Cannabinoid Injections into the Rat Periaqueductal Gray Enhances Subsequent Morphine Antinociception
- Characteristics of tolerance in the guinea pig ileum produced by chronic in vivo exposure to opioid versus cannabinoid agonists.
- Reduction of stress‐induced analgesia but not of exogenous opioid effects in mice lacking CB1 receptors
- The cannabinoid receptor 1 associates with NMDA receptors to produce glutamatergic hypofunction: implications in psychosis and schizophrenia
- Cannabinoid receptors and pain.
- Antinociceptive Synergy between Δ9-Tetrahydrocannabinol and Opioids after Oral Administration
- Comparative characterization in the rat of the interaction between cannabinoids and opiates for their immunosuppressive and analgesic effects.
- The interaction of cannabinoids and opioids on pentylenetetrazole-induced seizure threshold in mice.
- Dissociation of the Pharmacological Effects of THC by mTOR Blockade
- A role for central cannabinoid and opioid systems in peripheral delta 9-tetrahydrocannabinol-induced analgesia in mice.
- Endogenous opiates: 1994.
- A role of nitric oxide in WIN 55,212-2 tolerance in mice.
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