Vaso-occlusion by sickle cells: evidence for selective trapping of dense red cells.
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Summary
It is concluded that the progressive obstruction of the microcirculation by sickle cells involves selective sequestration of the densest classes of cells and that this mechanism might explain their partial disappearance during painful sickle cell crisis.
- Type
- article
- Published
- 1986-11-01
- Cited by
- 112
- References
- 14
- Access
- Open access
- OpenAlex
- https://openalex.org/W7956554
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:7219442
Keywords
Perfusion, Microcirculation, Occlusion, Chemistry, Vascular occlusion
References
- An objective sign in painful crisis in sickle cell anemia: the concomitant reduction of high density red cells.
- Response Characteristics of Perfused Microvessels To Pressure and Vasoactive Stimuli
- Pressure effects on the flow behavior of sickle (HbSS) red cells in isolated (ex-vivo) microvascular system.
- Erythrocytes in sickle cell anemia are heterogeneous in their rheological and hemodynamic characteristics.
- Human reticulocyte maturation and its relevance to erythropoietic stress.
- Separation of erythrocytes according to age on a simplified density gradient.
- Microvascular determinants of blood flow behavior and HbSS erythrocyte plugging in microcirculation.
- Human SS red cell rheological behavior in the microcirculation of cremaster muscle.
- The measurement of erythrocyte deformability using micropore membranes. A sensitive technique with clinical applications.
Cited by
- In vivo quantitation of water content in muscle tissues by NMR imaging.
- Sickle erythrocyte-endothelial interactions in microcirculation: the role of von Willebrand factor and implications for vasoocclusion.
- Sickle cell vasoocclusion: Many issues and some answers
- The pathophysiology of vascular obstruction in the sickle syndromes.
- Beyond hemoglobin polymerization: the red blood cell membrane and sickle disease pathophysiology.
- Demonstration of endothelial adhesion of sickle cells in vivo: a distinct role for deformable sickle cell discocytes.
- Two distinct pathways mediate the formation of intermediate density cells and hyperdense cells from normal density sickle red blood cells.
- Increased levels of endothelin-1 in plasma of sickle cell anemia patients.
- The efficacy of reducing agents or antioxidants in blocking the formation of dense cells and irreversibly sickled cells in vitro.
- Gαs proteins activate p72(Syk) and p60-c-Src tyrosine kinases to mediate sickle red blood cell adhesion to endothelium via LW-αvβ3 and CD44-CD44 interactions.
- Rheological consequences of sickle-cell dehydration
- Sickle cell anaemia – Rheology of the steady state and vaso-occlusive crisis
- Endothelial cells in physiology and in the pathophysiology of vascular disorders.
- Steady state hemoglobin concentration and packed cell volume in homozygous sickle cell disease patients in Lagos, Nigeria.
- Rheological and adherence properties of sickle cells. Potential contribution to hematologic manifestations of the disease.
- Sickle cell hemoglobin polymerization.
- Adaptation and survival of surface-deprived red blood cells in mice.
- Hemoglobin S gelation and sickle cell disease.
- MEK Inhibitors, Novel Anti-Adhesive Molecules, Reduce Sickle Red Blood Cell Adhesion In Vitro and In Vivo, and Vasoocclusion In Vivo
- Preliminary characterization of a structural defect in homozygous sickled cell alpha spectrin demonstrated by a rabbit autoantibody
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